Name: Tagetitoxin

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Type: small molecule

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Groups: experimental

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Indication: Not Available

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Accession Number: DB04788 ( DB04788)

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Description: Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.

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Structure:

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Prescription Products: Not Available

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Generic Prescription Products: Not Available

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Over the Counter Products: Not Available

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International Brands

• No Brands

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Brand Names

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Brand Mixtures

Brand Name	Ingredients

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Categories

• No Category

Indication: Not Available

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Pharmacodynamics: Not Available

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Mechanism of action: Tagetitoxin inhibits all RNAP catalytic reactions. Tagetitoxin binding is mediated exclusively through polar interactions with the beta and beta' residues whose substitutions confer resistance to tagetitoxin in vitro.

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Absorption: Not Available

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Volume of distribution: Not Available

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Protein binding: Not Available

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Metabolism: Not Available

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Route of elimination: Not Available

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Half life: Not Available

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Clearance: Not Available

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Toxicity: Not Available

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Affected organisms

• Not Available

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SNP Mediated Adverse Drug Reactions

• Not Available

Manufacturers:

• Not Available

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Packagers:

• Not Available

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Dosage forms

Form	Route	Strength

Form	Route	Strength

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Prices

Unit description	Cost	Unit

Unit description	Cost	Unit

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Patents

Country	Patent Number	Approved	Expires (estimated)

Drug Interactions

Drug	Interaction

Drug	Interaction

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Food Interactions:

• Not Available

Kingdom: Organic compounds

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Super Class: Not Available

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Class: Not Available

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Sub Class: Not Available

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Direct Parent: Not Available

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Alternative Parents:

• Acetate salts
• Carbonyl compounds
• Carboxylic acid esters
• Carboxylic acids
• Dialkyl ethers
• Dicarboxylic acids and derivatives
• Gamma amino acids and derivatives
• Hydrocarbon derivatives
• Monoalkyl phosphates
• Monoalkylamines
• Monosaccharides
• Organic phosphoric acids
• Oxacyclic compounds
• Oxanes
• Oxathianes
• Primary carboxylic acid amides
• Pyran carboxylic acids
• Thioethers

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substituent:

• 1,4-oxathiane
• Acetate salt
• Aliphatic heteropolycyclic compound
• Alkyl phosphate
• Amine
• Carbonyl group
• Carboxamide group
• Carboxylic acid
• Carboxylic acid amide
• Carboxylic acid ester
• Delta amino acid or derivatives
• Dialkyl ether
• Dicarboxylic acid or derivatives
• Ether
• Gamma amino acid or derivatives
• Hydrocarbon derivative
• Monoalkyl phosphate
• Monosaccharide
• Organic phosphate
• Organic phosphoric acid derivative
• Organoheterocyclic compound
• Organonitrogen compound
• Organooxygen compound
• Oxacycle
• Oxane
• Phosphoric acid ester
• Primary aliphatic amine
• Primary amine
• Primary carboxylic acid amide
• Pyran
• Pyran carboxylic acid
• Pyran carboxylic acid or derivatives
• Thioether

Synthesis Reference: Not Available

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General Reference: # Plet JR, Porter MJ: Synthesis of the bicyclic core of tagetitoxin. Chem Commun (Camb). 2006 Mar 21;(11):1197-9. Epub 2006 Feb 14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16518489 # Vassylyev DG, Svetlov V, Vassylyeva MN, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Artsimovitch I: Structural basis for transcription inhibition by tagetitoxin. Nat Struct Mol Biol. 2005 Dec;12(12):1086-93. Epub 2005 Nov 6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16273103 # Mathews DE, Durbin RD: Mechanistic aspects of tagetitoxin inhibition of RNA polymerase from Escherichia coli. Biochemistry. 1994 Oct 4;33(39):11987-92. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7918417 # Steinberg TH, Mathews DE, Durbin RD, Burgess RR: Tagetitoxin: a new inhibitor of eukaryotic transcription by RNA polymerase III. J Biol Chem. 1990 Jan 5;265(1):499-505. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2403565

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External Links:

Resource	Link

Resource	Link

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ATC Codes:

• Not Available

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AHFS Codes:

• Not Available

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MSDS: Download