Detail

Tagetitoxin

Description

Name: Tagetitoxin
Type: small molecule
Groups: experimental
Indication: Not Available
Accession Number: DB04788 ( DB04788)
Description: Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients

Categories
  • No Category

Pharmacology

Indication: Not Available
Pharmacodynamics: Not Available
Mechanism of action: Tagetitoxin inhibits all RNAP catalytic reactions. Tagetitoxin binding is mediated exclusively through polar interactions with the beta and beta' residues whose substitutions confer resistance to tagetitoxin in vitro.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
  • Not Available

Dosage forms
FormRouteStrength

Prices
Unit descriptionCostUnit

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Acetate salts
  • Carbonyl compounds
  • Carboxylic acid esters
  • Carboxylic acids
  • Dialkyl ethers
  • Dicarboxylic acids and derivatives
  • Gamma amino acids and derivatives
  • Hydrocarbon derivatives
  • Monoalkyl phosphates
  • Monoalkylamines
  • Monosaccharides
  • Organic phosphoric acids
  • Oxacyclic compounds
  • Oxanes
  • Oxathianes
  • Primary carboxylic acid amides
  • Pyran carboxylic acids
  • Thioethers

substituent:
  • 1,4-oxathiane
  • Acetate salt
  • Aliphatic heteropolycyclic compound
  • Alkyl phosphate
  • Amine
  • Carbonyl group
  • Carboxamide group
  • Carboxylic acid
  • Carboxylic acid amide
  • Carboxylic acid ester
  • Delta amino acid or derivatives
  • Dialkyl ether
  • Dicarboxylic acid or derivatives
  • Ether
  • Gamma amino acid or derivatives
  • Hydrocarbon derivative
  • Monoalkyl phosphate
  • Monosaccharide
  • Organic phosphate
  • Organic phosphoric acid derivative
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Organooxygen compound
  • Oxacycle
  • Oxane
  • Phosphoric acid ester
  • Primary aliphatic amine
  • Primary amine
  • Primary carboxylic acid amide
  • Pyran
  • Pyran carboxylic acid
  • Pyran carboxylic acid or derivatives
  • Thioether

References

Synthesis Reference: Not Available
General Reference: # Plet JR, Porter MJ: Synthesis of the bicyclic core of tagetitoxin. Chem Commun (Camb). 2006 Mar 21;(11):1197-9. Epub 2006 Feb 14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16518489 # Vassylyev DG, Svetlov V, Vassylyeva MN, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Artsimovitch I: Structural basis for transcription inhibition by tagetitoxin. Nat Struct Mol Biol. 2005 Dec;12(12):1086-93. Epub 2005 Nov 6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16273103 # Mathews DE, Durbin RD: Mechanistic aspects of tagetitoxin inhibition of RNA polymerase from Escherichia coli. Biochemistry. 1994 Oct 4;33(39):11987-92. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7918417 # Steinberg TH, Mathews DE, Durbin RD, Burgess RR: Tagetitoxin: a new inhibitor of eukaryotic transcription by RNA polymerase III. J Biol Chem. 1990 Jan 5;265(1):499-505. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2403565
External Links:
ResourceLink

ATC Codes:
  • Not Available

AHFS Codes:
  • Not Available

MSDS: Download
SiteLock

© Copyright 2022 The Purple Society, Purple Gladiator, Trialsmap, The Purple Drug Guide, and One Person CAN Make A Difference! are all registered trademarks of The Purple Society. The Purple Society, a not-for-profit, section 501(c)(3) #273785281.

The Purple Society website is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through this site should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.

CONTACT US

The Purple Society team is here for you 24 hours a day, 7 days a week. Send us an email and we'll get right back to you.

Sending
or

Log in with your credentials

Forgot your details?