Name: Tagetitoxin
Type: small molecule
Groups: experimental
Indication: Not Available
Accession Number: DB04788 ( DB04788)
Description: Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients

  • No Category


Indication: Not Available
Pharmacodynamics: Not Available
Mechanism of action: Tagetitoxin inhibits all RNAP catalytic reactions. Tagetitoxin binding is mediated exclusively through polar interactions with the beta and beta' residues whose substitutions confer resistance to tagetitoxin in vitro.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available


  • Not Available

  • Not Available

Dosage forms

Unit descriptionCostUnit

CountryPatent NumberApprovedExpires (estimated)


Drug Interactions

Food Interactions:
  • Not Available


Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Acetate salts
  • Carbonyl compounds
  • Carboxylic acid esters
  • Carboxylic acids
  • Dialkyl ethers
  • Dicarboxylic acids and derivatives
  • Gamma amino acids and derivatives
  • Hydrocarbon derivatives
  • Monoalkyl phosphates
  • Monoalkylamines
  • Monosaccharides
  • Organic phosphoric acids
  • Oxacyclic compounds
  • Oxanes
  • Oxathianes
  • Primary carboxylic acid amides
  • Pyran carboxylic acids
  • Thioethers

  • 1,4-oxathiane
  • Acetate salt
  • Aliphatic heteropolycyclic compound
  • Alkyl phosphate
  • Amine
  • Carbonyl group
  • Carboxamide group
  • Carboxylic acid
  • Carboxylic acid amide
  • Carboxylic acid ester
  • Delta amino acid or derivatives
  • Dialkyl ether
  • Dicarboxylic acid or derivatives
  • Ether
  • Gamma amino acid or derivatives
  • Hydrocarbon derivative
  • Monoalkyl phosphate
  • Monosaccharide
  • Organic phosphate
  • Organic phosphoric acid derivative
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Organooxygen compound
  • Oxacycle
  • Oxane
  • Phosphoric acid ester
  • Primary aliphatic amine
  • Primary amine
  • Primary carboxylic acid amide
  • Pyran
  • Pyran carboxylic acid
  • Pyran carboxylic acid or derivatives
  • Thioether


Synthesis Reference: Not Available
General Reference: # Plet JR, Porter MJ: Synthesis of the bicyclic core of tagetitoxin. Chem Commun (Camb). 2006 Mar 21;(11):1197-9. Epub 2006 Feb 14. "Pubmed": # Vassylyev DG, Svetlov V, Vassylyeva MN, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Artsimovitch I: Structural basis for transcription inhibition by tagetitoxin. Nat Struct Mol Biol. 2005 Dec;12(12):1086-93. Epub 2005 Nov 6. "Pubmed": # Mathews DE, Durbin RD: Mechanistic aspects of tagetitoxin inhibition of RNA polymerase from Escherichia coli. Biochemistry. 1994 Oct 4;33(39):11987-92. "Pubmed": # Steinberg TH, Mathews DE, Durbin RD, Burgess RR: Tagetitoxin: a new inhibitor of eukaryotic transcription by RNA polymerase III. J Biol Chem. 1990 Jan 5;265(1):499-505. "Pubmed":
External Links:

ATC Codes:
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AHFS Codes:
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MSDS: Download

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