Detail

TAK-390MR

Description

Name: TAK-390MR
Type: small molecule
Groups: investigational
Indication: Investigated for use/treatment in duodenal ulcers, gastric ulcers, gastroesophageal reflux disease (GERD), and gastrointestinal diseases and disorders (miscellaneous).
Accession Number: DB05351 ( DB05351)
Description: TAK-390MR is an investigational for the treatment of acid related disorders.. TAK-390MR employs a new modified release (MR) technology on an enantiomer of lansoprazole.
Structure:
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Dexilantcapsule, delayed release60 mg/1oral12-04-2010US
Dexilantcapsule (delayed release)30 mgoral05-08-2010Canada
Dexilantcapsule (delayed release)60 mgoral05-08-2010Canada
Dexilantcapsule, delayed release30 mg/1oral12-04-2010US
Dexilantcapsule, delayed release60 mg/1oral12-04-2010US
Dexilantcapsule, delayed release60 mg/1oral19-08-2010US
Dexilant Solutabtablet, orally disintegrating, delayed release30 mg/1oral26-01-2016US
Kapidexcapsule, delayed release30 mg/1oral05-03-2009US

Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
KapidexTAK-390MR
DexilantTAK-390MR
DexilantTAK-390MR
DexilantTAK-390MR
DexilantTAK-390MR
DexilantTAK-390MR
DexilantTAK-390MR
Dexilant SolutabTAK-390MR

Categories
  • Enzyme Inhibitors
  • Anti-Ulcer Agents
  • Anti-Infective Agents

Pharmacology

Indication: Investigated for use/treatment in duodenal ulcers, gastric ulcers, gastroesophageal reflux disease (GERD), and gastrointestinal diseases and disorders (miscellaneous).
Pharmacodynamics: Not Available
Mechanism of action: Lansoprazole has an asymmetric sulfur in its chemical structure and is commercially marketed as a racemic mixture. Both the (R)- and (S)-enantiomers of lansoprazole inhibit acid formation in isolated canine parietal cells and (H'+'/K'+')-ATPase in canine gastric microsomes with nearly the same potency.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
  • Not Available

Dosage forms
FormRouteStrength
Capsule (delayed release)oral30 mg
Capsule (delayed release)oral60 mg
Capsule, delayed releaseoral60 mg/1
Tablet, orally disintegrating, delayed releaseoral30 mg/1
Capsule, delayed releaseoral30 mg/1

Prices
Unit descriptionCostUnit

Patents
CountryPatent NumberApprovedExpires (estimated)
1327010Canada1994-02-152011-02-15
2375201Canada2010-02-092020-06-15
6462058United States2000-12-152020-12-15

Interactions

Drug Interactions
DrugInteraction
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with TAK-390MR resulting in a loss in efficacy.

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Not Available
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Not Available

substituent:
  • Not Available

References

Synthesis Reference: Not Available
General Reference: Not Available
External Links:
ResourceLink

ATC Codes:
  • Array

AHFS Codes:
  • Not Available

MSDS: Download
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