Detail

T487

Description

Name: T487
Type: small molecule
Groups: investigational
Indication: Investigated for use/treatment in inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.
Accession Number: DB05474 ( DB05474)
Description: T487 is a small molecule chemokine receptor antagonist to correct or modify immune system responses. It binds selectively and potently to CXCR3. The formulation is administered orally and has anti-inflammatory effects in conditions such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
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Pharmacology

Indication: Investigated for use/treatment in inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.
Pharmacodynamics: Not Available
Mechanism of action: T487 binds selectively and potently to CXCR3.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Well-tolerated in clinical trials for psorasis.
Affected organisms
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SNP Mediated Adverse Drug Reactions
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Pharmacoeconomics

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Interactions

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Food Interactions:
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Taxonomy

Kingdom: Not Available
Super Class: Not Available
Class: Not Available
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Direct Parent: Not Available
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substituent:
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References

Synthesis Reference: Not Available
General Reference: # Heise CE, Pahuja A, Hudson SC, Mistry MS, Putnam AL, Gross MM, Gottlieb PA, Wade WS, Kiankarimi M, Schwarz D, Crowe P, Zlotnik A, Alleva DG: Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71. Epub 2005 Mar 10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15761110
External Links:
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ATC Codes:
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AHFS Codes:
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MSDS: Download
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