Detail

T131

Description

Name: T131
Type: small molecule
Groups: investigational
Indication: Investigated for use/treatment in diabetes mellitus type 2.
Accession Number: DB05490 ( DB05490)
Description: T131, an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor involved in regulating the body’s ability to respond to insulin. T131 is not structurally related to the thiazolidinedione class of PPARg agonists, which includes Actos and Avandia.
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients

Categories
  • No Category

Pharmacology

Indication: Investigated for use/treatment in diabetes mellitus type 2.
Pharmacodynamics: Not Available
Mechanism of action: T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor involved in regulating the body’s ability to respond to insulin. T131 is not structurally related to the thiazolidinedione class of PPARg agonists, which includes Actos and Avandia
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: In preclinical studies comparing T131 to Avandia, T131 demonstrated superior potency and an improved side effect profile. In these studies, T131 treatment did not result in fluid retention or cardiac hypertrophy. In Phase 1 studies with T131, all doses were well tolerated and no serious adverse events were observed.
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
  • Not Available

Dosage forms
FormRouteStrength

Prices
Unit descriptionCostUnit

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Alpha amino acid amides
  • Amino fatty acids
  • Amphetamines and derivatives
  • Azacyclic compounds
  • Carbonyl compounds
  • Carboximidamides
  • Carboxylic acids
  • Cyclic peptides
  • Guanidines
  • Hydrocarbon derivatives
  • Imines
  • Lactams
  • Macrolactams
  • Monoalkylamines
  • Monocarboxylic acids and derivatives
  • N-acyl amines
  • N-acyl-L-alpha-amino acids
  • N-acyl-aliphatic-alpha amino acids
  • Organic disulfides
  • Phenols and derivatives
  • Phenylpropylamines
  • Pyrrolidines
  • Secondary carboxylic acid amides
  • Tertiary amines
  • Tertiary carboxylic acid amides

substituent:
  • Alpha-amino acid amide
  • Alpha-amino acid or derivatives
  • Amine
  • Amino fatty acid
  • Amphetamine or derivatives
  • Aromatic heteropolycyclic compound
  • Azacycle
  • Benzenoid
  • Carbonyl group
  • Carboxamide group
  • Carboximidamide
  • Carboxylic acid
  • Carboxylic acid amide
  • Carboxylic acid derivative
  • Cyclic alpha peptide
  • Fatty acyl
  • Fatty amide
  • Guanidine
  • Hydrocarbon derivative
  • Imine
  • Lactam
  • Macrolactam
  • Monocarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • N-acyl-aliphatic-alpha amino acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • N-acyl-amine
  • N-acyl-l-alpha-amino acid
  • N-substituted-alpha-amino acid
  • Organic disulfide
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Organooxygen compound
  • Phenol
  • Phenylpropylamine
  • Polypeptide
  • Primary aliphatic amine
  • Primary amine
  • Pyrrolidine
  • Secondary carboxylic acid amide
  • Tertiary amine
  • Tertiary carboxylic acid amide

References

Synthesis Reference: Not Available
General Reference: Not Available
External Links:
ResourceLink

ATC Codes:
  • Not Available

AHFS Codes:
  • Not Available

MSDS: Download
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