Detail

Magnesium salicylate

Description

Name: Magnesium salicylate
Type: small molecule
Groups: approved
Indication: Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain
Accession Number: DB01397 ( DB01397)
Description: Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain. It is also used to treat headaches, general back pain, and certain joint pains like arthritis. It is found in a variety of over-the-counter (OTC) medications as an anti-inflammatory, primarily for back-pain relief. Magnesium Salicylate can be an effective OTC alternative to prescription NSAIDs, with both anti-inflamatory and pain-relieving effects. Though the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results.
Structure:
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Back RelieftabletArrayoral14-05-2013US
Back-ese M Tab 325mgtablet325 mgArray31-12-198525-06-1998Canada
Diurex Water Pillstablet, coatedArrayoral15-05-2005US
Medique Back Pain Offtablet, film coatedArrayoral30-12-2008US
Otis Clapp Back Quelltablet, film coatedArrayoral30-12-2008US
Pain Aid BrftabletArrayoral19-08-2012US
Pamprin Cramp Menstrual Pain RelieftabletArrayoral01-01-1983US
Vica-cettabletArrayoral03-04-2015US

Generic Prescription Products: Not Available
Over the Counter Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Arthriten Tabletstablet325 mgoral15-05-200327-07-2006Canada
Back-ese M Tablets 325 mgtablet325 mgoral31-12-198019-07-2000Canada
Backache Aidtablet, film coated580 mg/1oral07-11-1998US
Backache Relieftablet, film coated580 mg/1oral07-11-1998US
Backache Relieftablet, film coated580 mg/1oral07-11-1998US
Backache Relief Extra Strengthtablet580 mg/1oral07-11-1998US
Backache Relief Extra Strengthtablet, film coated580 mg/1oral07-11-1998US
Doan's Backache Pills 325mgtablet325 mgoral31-12-198808-07-1998Canada
Doans Extra Strengthtablet580 mg/1oral15-05-2013US
Extra Strength Backache Reliefcapsule580 mg/1oral07-11-1998US
Herbogesictablet650 mgoral31-12-198806-07-2009Canada
Kneerelief Tabletstablet650 mgoral15-05-200327-07-2006Canada

International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
Backache Relief Extra StrengthMagnesium salicylate
Back ReliefAcetaminophen + Magnesium salicylate
Backache ReliefMagnesium salicylate
Pain Aid BrfMagnesium salicylate + Acetaminophen
Pamprin Cramp Menstrual Pain ReliefAcetaminophen + Magnesium salicylate + Pamabrom
Medique Back Pain OffMagnesium salicylate + Caffeine + Acetaminophen
Otis Clapp Back QuellMagnesium salicylate + Acetaminophen
Backache Relief Extra StrengthMagnesium salicylate
Diurex Water PillsMagnesium salicylate + Caffeine
Extra Strength Backache ReliefMagnesium salicylate
Doans Extra StrengthMagnesium salicylate
Backache ReliefMagnesium salicylate
Vica-cetMagnesium salicylate + Acetaminophen
Back-ese M Tablets 325 mgMagnesium salicylate
Back-ese M Tab 325mgMagnesium salicylate
Arthriten TabletsMagnesium salicylate
Kneerelief TabletsMagnesium salicylate
Doan's Backache Pills 325mgMagnesium salicylate
HerbogesicMagnesium salicylate
Backache AidMagnesium salicylate

Categories
  • No Category

Pharmacology

Indication: Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain
Pharmacodynamics: Not Available
Mechanism of action: Most NSAIDs act as nonselective inhibitors of the enzyme cyclooxygenase (COX), inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
Dosage forms
FormRouteStrength
Tabletoral
Tablet325 mg
Tabletoral325 mg
Tablet, film coatedoral580 mg/1
Tabletoral580 mg/1
Tablet, coatedoral
Capsuleoral580 mg/1
Tabletoral650 mg
Tablet, film coatedoral

Prices
Unit descriptionCostUnit
Choline mag trisal 1 gm tablet$1.15tablet
Tricosal 1000 mg tablet$1.23tablet
Keygesic-10 650 mg tablet$0.05tablet
CVS Pharmacy backache rlf 580 mg caplet$0.18caplet
Doan's regular 325 mg tablet$0.18tablet
Doan's ex strength 580 mg tablet$0.22tablet
Choline mag trisal 500 mg tablet$0.64tablet
Novasal 600 mg tablet$0.75tablet
Choline mag trisal 750 mg tablet$0.81tablet

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction
AbciximabMagnesium salicylate may increase the anticoagulant activities of Abciximab.
AcenocoumarolMagnesium salicylate may increase the anticoagulant activities of Acenocoumarol.
AcetazolamideThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Acetazolamide.
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Magnesium salicylate.
AlfacalcidolThe serum concentration of Magnesium salicylate can be increased when it is combined with Alfacalcidol.
AlteplaseThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Alteplase.
AmlodipineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Magnesium salicylate.
Ammonium chlorideThe serum concentration of Magnesium salicylate can be increased when it is combined with Ammonium chloride.
AmrinoneThe risk or severity of adverse effects can be increased when Amrinone is combined with Magnesium salicylate.
AnistreplaseThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Anistreplase.
BepridilThe risk or severity of adverse effects can be increased when Bepridil is combined with Magnesium salicylate.
CalcitriolThe serum concentration of Magnesium salicylate can be increased when it is combined with Calcitriol.
Citric AcidMagnesium salicylate may increase the anticoagulant activities of Citric Acid.
DalteparinMagnesium salicylate may increase the anticoagulant activities of Dalteparin.
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Magnesium salicylate.
DesmopressinThe risk or severity of adverse effects can be increased when Desmopressin is combined with Magnesium salicylate.
DexketoprofenThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Dexketoprofen.
DiclofenamideThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Diclofenamide.
DicoumarolMagnesium salicylate may increase the anticoagulant activities of Dicoumarol.
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Magnesium salicylate.
Edetic AcidMagnesium salicylate may increase the anticoagulant activities of Edetic Acid.
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Magnesium salicylate.
EnoxaparinMagnesium salicylate may increase the anticoagulant activities of Enoxaparin.
EthoxzolamideThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Ethoxzolamide.
Ethyl biscoumacetateMagnesium salicylate may increase the anticoagulant activities of Ethyl biscoumacetate.
FelodipineThe risk or severity of adverse effects can be increased when Felodipine is combined with Magnesium salicylate.
FludrocortisoneThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Fludrocortisone.
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Magnesium salicylate.
Fondaparinux sodiumMagnesium salicylate may increase the anticoagulant activities of Fondaparinux sodium.
GabapentinMagnesium salicylate may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
Ginkgo bilobaGinkgo biloba may increase the anticoagulant activities of Magnesium salicylate.
HeparinMagnesium salicylate may increase the anticoagulant activities of Heparin.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Magnesium salicylate.
Insulin RegularMagnesium salicylate may increase the hypoglycemic activities of Insulin Regular.
IsradipineThe risk or severity of adverse effects can be increased when Isradipine is combined with Magnesium salicylate.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium salicylate.
LercanidipineThe risk or severity of adverse effects can be increased when Lercanidipine is combined with Magnesium salicylate.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium salicylate.
Lipoic AcidMagnesium salicylate can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Magnesium salicylate.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Magnesium salicylate.
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Magnesium salicylate.
NicardipineThe risk or severity of adverse effects can be increased when Nicardipine is combined with Magnesium salicylate.
NimodipineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Magnesium salicylate.
NisoldipineThe risk or severity of adverse effects can be increased when Nisoldipine is combined with Magnesium salicylate.
NitrendipineThe risk or severity of adverse effects can be increased when Nitrendipine is combined with Magnesium salicylate.
OxytetracyclineMagnesium salicylate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
PerhexilineThe risk or severity of adverse effects can be increased when Perhexiline is combined with Magnesium salicylate.
PerindoprilMagnesium salicylate may decrease the antihypertensive activities of Perindopril.
PhenindioneMagnesium salicylate may increase the anticoagulant activities of Phenindione.
PhenprocoumonMagnesium salicylate may increase the anticoagulant activities of Phenprocoumon.
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Magnesium salicylate.
PrenylamineThe risk or severity of adverse effects can be increased when Prenylamine is combined with Magnesium salicylate.
ProbenecidThe therapeutic efficacy of Probenecid can be decreased when used in combination with Magnesium salicylate.
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Magnesium salicylate.
ReteplaseThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Reteplase.
RidogrelThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Ridogrel.
RisedronateThe risk or severity of adverse effects can be increased when Risedronate is combined with Magnesium salicylate.
Salicylate-sodiumSalicylate-sodium may increase the anticoagulant activities of Magnesium salicylate.
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Magnesium salicylate.
StreptokinaseThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Streptokinase.
SulodexideMagnesium salicylate may increase the anticoagulant activities of Sulodexide.
TenecteplaseThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Tenecteplase.
TorasemideMagnesium salicylate may decrease the diuretic activities of Torasemide.
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Magnesium salicylate.
TriethylenetetramineThe serum concentration of Magnesium salicylate can be decreased when it is combined with Triethylenetetramine.
UrokinaseThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Urokinase.
Valproic AcidThe serum concentration of Valproic Acid can be increased when it is combined with Magnesium salicylate.
VerapamilThe risk or severity of adverse effects can be increased when Verapamil is combined with Magnesium salicylate.
WarfarinMagnesium salicylate may increase the anticoagulant activities of Warfarin.

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Benzoic acids
  • Benzoyl derivatives
  • Carbonyl compounds
  • Carboxylic acids
  • Hydrocarbon derivatives
  • Monocarboxylic acids and derivatives
  • Organic salts
  • Organic zwitterions
  • Phenols and derivatives
  • Vinylogous acids

substituent:
  • Aromatic homomonocyclic compound
  • Benzoic acid
  • Benzoyl
  • Carbonyl group
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Monocarboxylic acid or derivatives
  • Organic salt
  • Organic zwitterion
  • Organooxygen compound
  • Phenol
  • Salicylic acid
  • Vinylogous acid

References

Synthesis Reference: Satishchandra P. Patel, Vinayak T. Bhalani, "Solid choline magnesium salicylate composition and method of preparing same." U.S. Patent US5043168, issued May, 1954.
General Reference: Not Available
External Links:
ResourceLink

ATC Codes:
  • Not Available

AHFS Codes:
  • Not Available

MSDS: Download
SiteLock

© Copyright 2022 The Purple Society, Purple Gladiator, Trialsmap, The Purple Drug Guide, and One Person CAN Make A Difference! are all registered trademarks of The Purple Society. The Purple Society, a not-for-profit, section 501(c)(3) #273785281.

The Purple Society website is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through this site should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.

CONTACT US

The Purple Society team is here for you 24 hours a day, 7 days a week. Send us an email and we'll get right back to you.

Sending
or

Log in with your credentials

Forgot your details?