Name: Magnesium salicylate

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Type: small molecule

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Groups: approved

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Indication: Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain

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Accession Number: DB01397 ( DB01397)

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Description: Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain. It is also used to treat headaches, general back pain, and certain joint pains like arthritis. It is found in a variety of over-the-counter (OTC) medications as an anti-inflammatory, primarily for back-pain relief. Magnesium Salicylate can be an effective OTC alternative to prescription NSAIDs, with both anti-inflamatory and pain-relieving effects. Though the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results.

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Structure:

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Prescription Products:

Name	Dosage	Strength	Route	Marketing Start	Marketing End	Country
Back Relief	tablet	Array	oral	14-05-2013		US
Back-ese M Tab 325mg	tablet	325 mg	Array	31-12-1985	25-06-1998	Canada
Diurex Water Pills	tablet, coated	Array	oral	15-05-2005		US
Medique Back Pain Off	tablet, film coated	Array	oral	30-12-2008		US
Otis Clapp Back Quell	tablet, film coated	Array	oral	30-12-2008		US
Pain Aid Brf	tablet	Array	oral	19-08-2012		US
Pamprin Cramp Menstrual Pain Relief	tablet	Array	oral	01-01-1983		US
Vica-cet	tablet	Array	oral	03-04-2015		US

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Generic Prescription Products: Not Available

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Over the Counter Products:

Name	Dosage	Strength	Route	Marketing Start	Marketing End	Country
Arthriten Tablets	tablet	325 mg	oral	15-05-2003	27-07-2006	Canada
Back-ese M Tablets 325 mg	tablet	325 mg	oral	31-12-1980	19-07-2000	Canada
Backache Aid	tablet, film coated	580 mg/1	oral	07-11-1998		US
Backache Relief	tablet, film coated	580 mg/1	oral	07-11-1998		US
Backache Relief	tablet, film coated	580 mg/1	oral	07-11-1998		US
Backache Relief Extra Strength	tablet	580 mg/1	oral	07-11-1998		US
Backache Relief Extra Strength	tablet, film coated	580 mg/1	oral	07-11-1998		US
Doan's Backache Pills 325mg	tablet	325 mg	oral	31-12-1988	08-07-1998	Canada
Doans Extra Strength	tablet	580 mg/1	oral	15-05-2013		US
Extra Strength Backache Relief	capsule	580 mg/1	oral	07-11-1998		US
Herbogesic	tablet	650 mg	oral	31-12-1988	06-07-2009	Canada
Kneerelief Tablets	tablet	650 mg	oral	15-05-2003	27-07-2006	Canada

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International Brands

• No Brands

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Brand Names

• No Brands

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Brand Mixtures

Brand Name	Ingredients
Backache Relief Extra Strength	Magnesium salicylate
Back Relief	Acetaminophen + Magnesium salicylate
Backache Relief	Magnesium salicylate
Pain Aid Brf	Magnesium salicylate + Acetaminophen
Pamprin Cramp Menstrual Pain Relief	Acetaminophen + Magnesium salicylate + Pamabrom
Medique Back Pain Off	Magnesium salicylate + Caffeine + Acetaminophen
Otis Clapp Back Quell	Magnesium salicylate + Acetaminophen
Backache Relief Extra Strength	Magnesium salicylate
Diurex Water Pills	Magnesium salicylate + Caffeine
Extra Strength Backache Relief	Magnesium salicylate
Doans Extra Strength	Magnesium salicylate
Backache Relief	Magnesium salicylate
Vica-cet	Magnesium salicylate + Acetaminophen
Back-ese M Tablets 325 mg	Magnesium salicylate
Back-ese M Tab 325mg	Magnesium salicylate
Arthriten Tablets	Magnesium salicylate
Kneerelief Tablets	Magnesium salicylate
Doan's Backache Pills 325mg	Magnesium salicylate
Herbogesic	Magnesium salicylate
Backache Aid	Magnesium salicylate

Brand Name	Ingredients
Backache Relief Extra Strength	Magnesium salicylate
Back Relief	Acetaminophen + Magnesium salicylate
Backache Relief	Magnesium salicylate
Pain Aid Brf	Magnesium salicylate + Acetaminophen
Pamprin Cramp Menstrual Pain Relief	Acetaminophen + Magnesium salicylate + Pamabrom
Medique Back Pain Off	Magnesium salicylate + Caffeine + Acetaminophen
Otis Clapp Back Quell	Magnesium salicylate + Acetaminophen
Backache Relief Extra Strength	Magnesium salicylate
Diurex Water Pills	Magnesium salicylate + Caffeine
Extra Strength Backache Relief	Magnesium salicylate
Doans Extra Strength	Magnesium salicylate
Backache Relief	Magnesium salicylate
Vica-cet	Magnesium salicylate + Acetaminophen
Back-ese M Tablets 325 mg	Magnesium salicylate
Back-ese M Tab 325mg	Magnesium salicylate
Arthriten Tablets	Magnesium salicylate
Kneerelief Tablets	Magnesium salicylate
Doan's Backache Pills 325mg	Magnesium salicylate
Herbogesic	Magnesium salicylate
Backache Aid	Magnesium salicylate

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Categories

• No Category

Indication: Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain

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Pharmacodynamics: Not Available

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Mechanism of action: Most NSAIDs act as nonselective inhibitors of the enzyme cyclooxygenase (COX), inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation.

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Absorption: Not Available

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Volume of distribution: Not Available

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Protein binding: Not Available

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Metabolism: Not Available

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Route of elimination: Not Available

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Half life: Not Available

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Clearance: Not Available

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Toxicity: Not Available

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Affected organisms

• Not Available

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SNP Mediated Adverse Drug Reactions

• Not Available

Manufacturers:

• Not Available

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Packagers:

• Caraco Pharmaceutical Labs
• CVS Pharmacy
• Ivax Pharmaceuticals
• Key Co.
• Novartis AG
• Palmetto Pharmaceuticals Inc.
• Qualitest
• US Pharmaceutical Corp.

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Dosage forms

Form	Route	Strength
Tablet	oral
Tablet		325 mg
Tablet	oral	325 mg
Tablet, film coated	oral	580 mg/1
Tablet	oral	580 mg/1
Tablet, coated	oral
Capsule	oral	580 mg/1
Tablet	oral	650 mg
Tablet, film coated	oral

Form	Route	Strength
Tablet	oral
Tablet		325 mg
Tablet	oral	325 mg
Tablet, film coated	oral	580 mg/1
Tablet	oral	580 mg/1
Tablet, coated	oral
Capsule	oral	580 mg/1
Tablet	oral	650 mg
Tablet, film coated	oral

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Prices

Unit description	Cost	Unit
Choline mag trisal 1 gm tablet	$1.15	tablet
Tricosal 1000 mg tablet	$1.23	tablet
Keygesic-10 650 mg tablet	$0.05	tablet
CVS Pharmacy backache rlf 580 mg caplet	$0.18	caplet
Doan's regular 325 mg tablet	$0.18	tablet
Doan's ex strength 580 mg tablet	$0.22	tablet
Choline mag trisal 500 mg tablet	$0.64	tablet
Novasal 600 mg tablet	$0.75	tablet
Choline mag trisal 750 mg tablet	$0.81	tablet

Unit description	Cost	Unit
Choline mag trisal 1 gm tablet	$1.15	tablet
Tricosal 1000 mg tablet	$1.23	tablet
Keygesic-10 650 mg tablet	$0.05	tablet
CVS Pharmacy backache rlf 580 mg caplet	$0.18	caplet
Doan's regular 325 mg tablet	$0.18	tablet
Doan's ex strength 580 mg tablet	$0.22	tablet
Choline mag trisal 500 mg tablet	$0.64	tablet
Novasal 600 mg tablet	$0.75	tablet
Choline mag trisal 750 mg tablet	$0.81	tablet

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Patents

Country	Patent Number	Approved	Expires (estimated)

Drug Interactions

Drug	Interaction
Abciximab	Magnesium salicylate may increase the anticoagulant activities of Abciximab.
Acenocoumarol	Magnesium salicylate may increase the anticoagulant activities of Acenocoumarol.
Acetazolamide	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Acetazolamide.
Acetylsalicylic acid	Acetylsalicylic acid may increase the anticoagulant activities of Magnesium salicylate.
Alfacalcidol	The serum concentration of Magnesium salicylate can be increased when it is combined with Alfacalcidol.
Alteplase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Alteplase.
Amlodipine	The risk or severity of adverse effects can be increased when Amlodipine is combined with Magnesium salicylate.
Ammonium chloride	The serum concentration of Magnesium salicylate can be increased when it is combined with Ammonium chloride.
Amrinone	The risk or severity of adverse effects can be increased when Amrinone is combined with Magnesium salicylate.
Anistreplase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Anistreplase.
Bepridil	The risk or severity of adverse effects can be increased when Bepridil is combined with Magnesium salicylate.
Calcitriol	The serum concentration of Magnesium salicylate can be increased when it is combined with Calcitriol.
Citric Acid	Magnesium salicylate may increase the anticoagulant activities of Citric Acid.
Dalteparin	Magnesium salicylate may increase the anticoagulant activities of Dalteparin.
Deferiprone	The serum concentration of Deferiprone can be decreased when it is combined with Magnesium salicylate.
Desmopressin	The risk or severity of adverse effects can be increased when Desmopressin is combined with Magnesium salicylate.
Dexketoprofen	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Dexketoprofen.
Diclofenamide	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Diclofenamide.
Dicoumarol	Magnesium salicylate may increase the anticoagulant activities of Dicoumarol.
Dolutegravir	The serum concentration of Dolutegravir can be decreased when it is combined with Magnesium salicylate.
Edetic Acid	Magnesium salicylate may increase the anticoagulant activities of Edetic Acid.
Eltrombopag	The serum concentration of Eltrombopag can be decreased when it is combined with Magnesium salicylate.
Enoxaparin	Magnesium salicylate may increase the anticoagulant activities of Enoxaparin.
Ethoxzolamide	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Ethoxzolamide.
Ethyl biscoumacetate	Magnesium salicylate may increase the anticoagulant activities of Ethyl biscoumacetate.
Felodipine	The risk or severity of adverse effects can be increased when Felodipine is combined with Magnesium salicylate.
Fludrocortisone	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Fludrocortisone.
Flunarizine	The risk or severity of adverse effects can be increased when Flunarizine is combined with Magnesium salicylate.
Fondaparinux sodium	Magnesium salicylate may increase the anticoagulant activities of Fondaparinux sodium.
Gabapentin	Magnesium salicylate may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
Ginkgo biloba	Ginkgo biloba may increase the anticoagulant activities of Magnesium salicylate.
Heparin	Magnesium salicylate may increase the anticoagulant activities of Heparin.
Hyaluronidase	The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Magnesium salicylate.
Insulin Regular	Magnesium salicylate may increase the hypoglycemic activities of Insulin Regular.
Isradipine	The risk or severity of adverse effects can be increased when Isradipine is combined with Magnesium salicylate.
Lamotrigine	The risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium salicylate.
Lercanidipine	The risk or severity of adverse effects can be increased when Lercanidipine is combined with Magnesium salicylate.
Levothyroxine	The serum concentration of Levothyroxine can be decreased when it is combined with Magnesium salicylate.
Lipoic Acid	Magnesium salicylate can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Sulfate	The risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Magnesium salicylate.
Methotrexate	The serum concentration of Methotrexate can be increased when it is combined with Magnesium salicylate.
Mycophenolic acid	The serum concentration of Mycophenolic acid can be decreased when it is combined with Magnesium salicylate.
Nicardipine	The risk or severity of adverse effects can be increased when Nicardipine is combined with Magnesium salicylate.
Nimodipine	The risk or severity of adverse effects can be increased when Nimodipine is combined with Magnesium salicylate.
Nisoldipine	The risk or severity of adverse effects can be increased when Nisoldipine is combined with Magnesium salicylate.
Nitrendipine	The risk or severity of adverse effects can be increased when Nitrendipine is combined with Magnesium salicylate.
Oxytetracycline	Magnesium salicylate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Perhexiline	The risk or severity of adverse effects can be increased when Perhexiline is combined with Magnesium salicylate.
Perindopril	Magnesium salicylate may decrease the antihypertensive activities of Perindopril.
Phenindione	Magnesium salicylate may increase the anticoagulant activities of Phenindione.
Phenprocoumon	Magnesium salicylate may increase the anticoagulant activities of Phenprocoumon.
Pralatrexate	The serum concentration of Pralatrexate can be increased when it is combined with Magnesium salicylate.
Prenylamine	The risk or severity of adverse effects can be increased when Prenylamine is combined with Magnesium salicylate.
Probenecid	The therapeutic efficacy of Probenecid can be decreased when used in combination with Magnesium salicylate.
Raltegravir	The serum concentration of Raltegravir can be decreased when it is combined with Magnesium salicylate.
Reteplase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Reteplase.
Ridogrel	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Ridogrel.
Risedronate	The risk or severity of adverse effects can be increased when Risedronate is combined with Magnesium salicylate.
Salicylate-sodium	Salicylate-sodium may increase the anticoagulant activities of Magnesium salicylate.
Sparfloxacin	The serum concentration of Sparfloxacin can be decreased when it is combined with Magnesium salicylate.
Streptokinase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Streptokinase.
Sulodexide	Magnesium salicylate may increase the anticoagulant activities of Sulodexide.
Tenecteplase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Tenecteplase.
Torasemide	Magnesium salicylate may decrease the diuretic activities of Torasemide.
Treprostinil	The risk or severity of adverse effects can be increased when Treprostinil is combined with Magnesium salicylate.
Triethylenetetramine	The serum concentration of Magnesium salicylate can be decreased when it is combined with Triethylenetetramine.
Urokinase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Urokinase.
Valproic Acid	The serum concentration of Valproic Acid can be increased when it is combined with Magnesium salicylate.
Verapamil	The risk or severity of adverse effects can be increased when Verapamil is combined with Magnesium salicylate.
Warfarin	Magnesium salicylate may increase the anticoagulant activities of Warfarin.

Drug	Interaction
Abciximab	Magnesium salicylate may increase the anticoagulant activities of Abciximab.
Acenocoumarol	Magnesium salicylate may increase the anticoagulant activities of Acenocoumarol.
Acetazolamide	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Acetazolamide.
Acetylsalicylic acid	Acetylsalicylic acid may increase the anticoagulant activities of Magnesium salicylate.
Alfacalcidol	The serum concentration of Magnesium salicylate can be increased when it is combined with Alfacalcidol.
Alteplase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Alteplase.
Amlodipine	The risk or severity of adverse effects can be increased when Amlodipine is combined with Magnesium salicylate.
Ammonium chloride	The serum concentration of Magnesium salicylate can be increased when it is combined with Ammonium chloride.
Amrinone	The risk or severity of adverse effects can be increased when Amrinone is combined with Magnesium salicylate.
Anistreplase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Anistreplase.
Bepridil	The risk or severity of adverse effects can be increased when Bepridil is combined with Magnesium salicylate.
Calcitriol	The serum concentration of Magnesium salicylate can be increased when it is combined with Calcitriol.
Citric Acid	Magnesium salicylate may increase the anticoagulant activities of Citric Acid.
Dalteparin	Magnesium salicylate may increase the anticoagulant activities of Dalteparin.
Deferiprone	The serum concentration of Deferiprone can be decreased when it is combined with Magnesium salicylate.
Desmopressin	The risk or severity of adverse effects can be increased when Desmopressin is combined with Magnesium salicylate.
Dexketoprofen	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Dexketoprofen.
Diclofenamide	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Diclofenamide.
Dicoumarol	Magnesium salicylate may increase the anticoagulant activities of Dicoumarol.
Dolutegravir	The serum concentration of Dolutegravir can be decreased when it is combined with Magnesium salicylate.
Edetic Acid	Magnesium salicylate may increase the anticoagulant activities of Edetic Acid.
Eltrombopag	The serum concentration of Eltrombopag can be decreased when it is combined with Magnesium salicylate.
Enoxaparin	Magnesium salicylate may increase the anticoagulant activities of Enoxaparin.
Ethoxzolamide	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Ethoxzolamide.
Ethyl biscoumacetate	Magnesium salicylate may increase the anticoagulant activities of Ethyl biscoumacetate.
Felodipine	The risk or severity of adverse effects can be increased when Felodipine is combined with Magnesium salicylate.
Fludrocortisone	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Fludrocortisone.
Flunarizine	The risk or severity of adverse effects can be increased when Flunarizine is combined with Magnesium salicylate.
Fondaparinux sodium	Magnesium salicylate may increase the anticoagulant activities of Fondaparinux sodium.
Gabapentin	Magnesium salicylate may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
Ginkgo biloba	Ginkgo biloba may increase the anticoagulant activities of Magnesium salicylate.
Heparin	Magnesium salicylate may increase the anticoagulant activities of Heparin.
Hyaluronidase	The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Magnesium salicylate.
Insulin Regular	Magnesium salicylate may increase the hypoglycemic activities of Insulin Regular.
Isradipine	The risk or severity of adverse effects can be increased when Isradipine is combined with Magnesium salicylate.
Lamotrigine	The risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium salicylate.
Lercanidipine	The risk or severity of adverse effects can be increased when Lercanidipine is combined with Magnesium salicylate.
Levothyroxine	The serum concentration of Levothyroxine can be decreased when it is combined with Magnesium salicylate.
Lipoic Acid	Magnesium salicylate can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Sulfate	The risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Magnesium salicylate.
Methotrexate	The serum concentration of Methotrexate can be increased when it is combined with Magnesium salicylate.
Mycophenolic acid	The serum concentration of Mycophenolic acid can be decreased when it is combined with Magnesium salicylate.
Nicardipine	The risk or severity of adverse effects can be increased when Nicardipine is combined with Magnesium salicylate.
Nimodipine	The risk or severity of adverse effects can be increased when Nimodipine is combined with Magnesium salicylate.
Nisoldipine	The risk or severity of adverse effects can be increased when Nisoldipine is combined with Magnesium salicylate.
Nitrendipine	The risk or severity of adverse effects can be increased when Nitrendipine is combined with Magnesium salicylate.
Oxytetracycline	Magnesium salicylate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Perhexiline	The risk or severity of adverse effects can be increased when Perhexiline is combined with Magnesium salicylate.
Perindopril	Magnesium salicylate may decrease the antihypertensive activities of Perindopril.
Phenindione	Magnesium salicylate may increase the anticoagulant activities of Phenindione.
Phenprocoumon	Magnesium salicylate may increase the anticoagulant activities of Phenprocoumon.
Pralatrexate	The serum concentration of Pralatrexate can be increased when it is combined with Magnesium salicylate.
Prenylamine	The risk or severity of adverse effects can be increased when Prenylamine is combined with Magnesium salicylate.
Probenecid	The therapeutic efficacy of Probenecid can be decreased when used in combination with Magnesium salicylate.
Raltegravir	The serum concentration of Raltegravir can be decreased when it is combined with Magnesium salicylate.
Reteplase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Reteplase.
Ridogrel	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Ridogrel.
Risedronate	The risk or severity of adverse effects can be increased when Risedronate is combined with Magnesium salicylate.
Salicylate-sodium	Salicylate-sodium may increase the anticoagulant activities of Magnesium salicylate.
Sparfloxacin	The serum concentration of Sparfloxacin can be decreased when it is combined with Magnesium salicylate.
Streptokinase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Streptokinase.
Sulodexide	Magnesium salicylate may increase the anticoagulant activities of Sulodexide.
Tenecteplase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Tenecteplase.
Torasemide	Magnesium salicylate may decrease the diuretic activities of Torasemide.
Treprostinil	The risk or severity of adverse effects can be increased when Treprostinil is combined with Magnesium salicylate.
Triethylenetetramine	The serum concentration of Magnesium salicylate can be decreased when it is combined with Triethylenetetramine.
Urokinase	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Urokinase.
Valproic Acid	The serum concentration of Valproic Acid can be increased when it is combined with Magnesium salicylate.
Verapamil	The risk or severity of adverse effects can be increased when Verapamil is combined with Magnesium salicylate.
Warfarin	Magnesium salicylate may increase the anticoagulant activities of Warfarin.

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Food Interactions:

• Not Available

Kingdom: Organic compounds

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Super Class: Not Available

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Class: Not Available

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Sub Class: Not Available

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Direct Parent: Not Available

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Alternative Parents:

• Benzoic acids
• Benzoyl derivatives
• Carbonyl compounds
• Carboxylic acids
• Hydrocarbon derivatives
• Monocarboxylic acids and derivatives
• Organic salts
• Organic zwitterions
• Phenols and derivatives
• Vinylogous acids

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substituent:

• Aromatic homomonocyclic compound
• Benzoic acid
• Benzoyl
• Carbonyl group
• Carboxylic acid
• Carboxylic acid derivative
• Hydrocarbon derivative
• Monocarboxylic acid or derivatives
• Organic salt
• Organic zwitterion
• Organooxygen compound
• Phenol
• Salicylic acid
• Vinylogous acid

Synthesis Reference: Satishchandra P. Patel, Vinayak T. Bhalani, "Solid choline magnesium salicylate composition and method of preparing same." U.S. Patent US5043168, issued May, 1954.

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General Reference: Not Available

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External Links:

Resource	Link

Resource	Link

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ATC Codes:

• Not Available

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AHFS Codes:

• Not Available

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MSDS: Download