Name: Mafenide
Type: small molecule
Groups: approved
Indication: Mafenide is indicated in the treatment of severe burns.
Accession Number: DB06795 ( DB06795)
Description: Mafenide is a sulfonamide-type medication used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Sulfamyloncream85 mg/gtopical08-12-2006US
Sulfamylonpowder, for solution50 g/1topical05-06-1998US
Sulfamylon Cream - 8.5%cream8.5 %topical07-03-199620-11-2008Canada

Generic Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Mafenide Acetatepowder, for solution50 g/1topical12-02-2013US

Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
Mafenide AcetateMafenide
Sulfamylon Cream - 8.5%Mafenide

  • No Category


Indication: Mafenide is indicated in the treatment of severe burns.
Pharmacodynamics: Not Available
Mechanism of action: The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.
Absorption: Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration.
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine.
Half life: Not Available
Clearance: Not Available
Toxicity: Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur. Mafenide is contraindicated in persons with renal impairment or sulfonamide hypersensitivity.
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available


  • Not Available

  • Not Available

Dosage forms
Powder, for solutiontopical50 g/1
Creamtopical85 mg/g
Creamtopical8.5 %

Unit descriptionCostUnit

CountryPatent NumberApprovedExpires (estimated)


Drug Interactions
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Mafenide.
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Mafenide.
PrilocaineThe risk or severity of adverse effects can be increased when Mafenide is combined with Prilocaine.
Sodium NitriteThe risk or severity of adverse effects can be increased when Mafenide is combined with Sodium Nitrite.
Sodium picosulfateThe therapeutic efficacy of Sodium picosulfate can be decreased when used in combination with Mafenide.

Food Interactions:
  • Not Available


Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Aminosulfonyl compounds
  • Aralkylamines
  • Benzylamines
  • Hydrocarbon derivatives
  • Monoalkylamines
  • Phenylmethylamines
  • Sulfonamides

  • Amine
  • Aminosulfonyl compound
  • Aralkylamine
  • Aromatic homomonocyclic compound
  • Benzenesulfonamide
  • Benzylamine
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organosulfur compound
  • Phenylmethylamine
  • Primary aliphatic amine
  • Primary amine
  • Sulfonamide
  • Sulfonic acid derivative
  • Sulfonyl


Synthesis Reference: U.S. Patent 2,288,531.
General Reference: # Maghsoudi H, Salehi F, Khosrowshahi MK, Baghaei M, Nasirzadeh M, Shams R: Comparison between topical honey and mafenide acetate in treatment of burn wounds. Ann Burns Fire Disasters. 2011 Sep 30;24(3):132-7. "Pubmed":
External Links:

ATC Codes:
  • Array

AHFS Codes:
  • Not Available

MSDS: Download

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