Detail

M40403

Description

Name: M40403
Type: biotech
Groups: investigational
Indication: Intended for the treatment of pain and possibly various forms of cancer.
Accession Number: DB04976 ( DB04976)
Description: M40403 is a low molecular weight, synthetic manganese containing superoxide dismutase mimetic (SODm) that selectively removes superoxide anion.
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
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Pharmacology

Indication: Intended for the treatment of pain and possibly various forms of cancer.
Pharmacodynamics: Not Available
Mechanism of action: M40403 is the lead candidate in a unique class of compounds known as superoxide dismutase (SOD) mimetics. These stable, low molecular weight compounds mimic the effect of superoxide dismutase, a naturally occurring enzyme designed to destroy superoxide free radicals present in various diseases associated with pain and inflammation.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms
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SNP Mediated Adverse Drug Reactions
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Pharmacoeconomics

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Interactions

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Food Interactions:
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Taxonomy

Kingdom: Organic Compounds
Super Class: Not Available
Class: Not Available
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Direct Parent: Not Available
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substituent:
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References

Synthesis Reference: Not Available
General Reference: # Salvemini D, Mazzon E, Dugo L, Riley DP, Serraino I, Caputi AP, Cuzzocrea S: Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403. Br J Pharmacol. 2001 Feb;132(4):815-27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11181422 # Cuzzocrea S, Mazzon E, Dugo L, Caputi AP, Riley DP, Salvemini D: Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis. Eur J Pharmacol. 2001 Nov 30;432(1):79-89. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11734191 # Masini E, Cuzzocrea S, Mazzon E, Marzocca C, Mannaioni PF, Salvemini D: Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12110615 # Wang C, McInnis J, West JB, Bao J, Anastasio N, Guidry JA, Ye Y, Salvemini D, Johnson KM: Blockade of phencyclidine-induced cortical apoptosis and deficits in prepulse inhibition by M40403, a superoxide dismutase mimetic. J Pharmacol Exp Ther. 2003 Jan;304(1):266-71. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12490600 # McFadden SL, Ding D, Salvemini D, Salvi RJ: M40403, a superoxide dismutase mimetic, protects cochlear hair cells from gentamicin, but not cisplatin toxicity. Toxicol Appl Pharmacol. 2003 Jan 1;186(1):46-54. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12583992 # Samlowski WE, Petersen R, Cuzzocrea S, Macarthur H, Burton D, McGregor JR, Salvemini D: A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects. Nat Med. 2003 Jun;9(6):750-5. Epub 2003 May 5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12730689 # Marzocca C, Vannacci A, Cuzzocrea S, Salvemini D, Mannaioni PF, Masini E: Effects of the SOD mimetic, M40403, on prostaglandin production in an in vivo model of ischemia and reperfusion in rat heart. Inflamm Res. 2003 Apr;52 Suppl 1:S23-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12755394 # Jiang F, Guo Y, Salvemini D, Dusting GJ: Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice. Br J Pharmacol. 2003 Jul;139(6):1127-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12871831 # Di Filippo C, Cuzzocrea S, Marfella R, Fabbroni V, Scollo G, Berrino L, Giugliano D, Rossi F, D'Amico M: M40403 prevents myocardial injury induced by acute hyperglycaemia in perfused rat heart. Eur J Pharmacol. 2004 Aug 16;497(1):65-74. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15321736
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ATC Codes:
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AHFS Codes:
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