Name: G4544

---

Type: small molecule

---

Groups: investigational

---

Indication: For treatment of non-Hodgkin's lymphoma, bone metastases, Paget's disease, and osteoporosis

---

Accession Number: DB05244 ( DB05244)

---

Description: G4544 is an oral gallium compound that enables oral absorption of the active ingredient contained in Ganite™ (gallium nitrate injection). It targets bone tissue and is actively incorporated into bone mineral at sites where bone is metabolically active.

---

Structure:

---

Prescription Products: Not Available

---

Generic Prescription Products: Not Available

---

Over the Counter Products: Not Available

---

International Brands

• No Brands

---

Brand Names

• No Brands

---

Brand Mixtures

Brand Name	Ingredients

Brand Name	Ingredients

---

Categories

• No Category

Indication: For treatment of non-Hodgkin's lymphoma, bone metastases, Paget's disease, and osteoporosis

---

Pharmacodynamics: Not Available

---

Mechanism of action: G4544 reduces bone loss by inhibiting calcium resorption from bone. Preclinical evidence suggests that the mechanism of G4544 action is multifactorial and different from other current therapies used to treat bone loss, such as estrogen or selective estrogen receptor modulators (SERMs), calcitonin, or bisphosphonates (e.g., Zometa or Fosamax). G4544 preferentially accumulates in metabolically active regions of bone, inhibits osteoclast-mediated bone resorption, and favorably alters bone mineral composition and properties.

---

Absorption: Orally bioavailable.

---

Volume of distribution: Not Available

---

Protein binding: Not Available

---

Metabolism: Not Available

---

Route of elimination: Not Available

---

Half life: Not Available

---

Clearance: Not Available

---

Toxicity: Not Available

---

Affected organisms

• Not Available

---

SNP Mediated Adverse Drug Reactions

• Not Available

Manufacturers:

• Not Available

---

Packagers:

• Not Available

---

Dosage forms

Form	Route	Strength

Form	Route	Strength

---

Prices

Unit description	Cost	Unit

Unit description	Cost	Unit

---

Patents

Country	Patent Number	Approved	Expires (estimated)

Drug Interactions

Drug	Interaction

Drug	Interaction

---

Food Interactions:

• Not Available

Kingdom: Not Available

---

Super Class: Not Available

---

Class: Not Available

---

Sub Class: Not Available

---

Direct Parent: Not Available

---

Alternative Parents:

• Not Available

---

substituent:

• Not Available

Synthesis Reference: Not Available

---

General Reference: Not Available

---

External Links:

Resource	Link

Resource	Link

---

ATC Codes:

• Not Available

---

AHFS Codes:

• Not Available

---

MSDS: Download