Name: G418

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Type: small molecule

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Groups: experimental

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Indication: Not Available

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Accession Number: DB04263 ( EXPT01586)

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Description: G418 (also known as Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II. G418 is commonly used in laboratory research to select genetically engineered cells.

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Structure:

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Prescription Products: Not Available

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Generic Prescription Products: Not Available

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Over the Counter Products: Not Available

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International Brands

• No Brands

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Brand Names

• No Brands

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Brand Mixtures

Brand Name	Ingredients

Brand Name	Ingredients

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Categories

• No Category

Indication: Not Available

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Pharmacodynamics: Not Available

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Mechanism of action: Not Available

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Absorption: Not Available

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Volume of distribution: Not Available

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Protein binding: Not Available

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Metabolism: Not Available

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Route of elimination: Not Available

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Half life: Not Available

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Clearance: Not Available

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Toxicity: Not Available

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Affected organisms

• Not Available

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SNP Mediated Adverse Drug Reactions

• Not Available

Manufacturers:

• Not Available

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Packagers:

• Not Available

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Dosage forms

Form	Route	Strength

Form	Route	Strength

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Prices

Unit description	Cost	Unit

Unit description	Cost	Unit

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Patents

Country	Patent Number	Approved	Expires (estimated)

Drug Interactions

Drug	Interaction

Drug	Interaction

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Food Interactions:

• Not Available

Kingdom: Organic compounds

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Super Class: Not Available

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Class: Not Available

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Sub Class: Not Available

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Direct Parent: Not Available

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Alternative Parents:

• 1,2-aminoalcohols
• 1,2-diols
• 2-deoxystreptamine aminoglycosides
• Acetals
• Amino sugars
• Cyclic alcohols and derivatives
• Cyclohexanols
• Cyclohexylamines
• Dialkylamines
• Hydrocarbon derivatives
• Monoalkylamines
• Monosaccharides
• O-glycosyl compounds
• Oxacyclic compounds
• Oxanes
• Tertiary alcohols

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substituent:

• 1,2-aminoalcohol
• 1,2-diol
• 2-deoxystreptamine aminoglycoside
• Acetal
• Alcohol
• Aliphatic heteromonocyclic compound
• Amine
• Amino sugar
• Aminoglycoside core
• Cyclic alcohol
• Cyclohexanol
• Cyclohexylamine
• Glucosamine
• Glycosyl compound
• Hydrocarbon derivative
• Monosaccharide
• O-glycosyl compound
• Organoheterocyclic compound
• Organonitrogen compound
• Oxacycle
• Oxane
• Primary aliphatic amine
• Primary amine
• Secondary alcohol
• Secondary aliphatic amine
• Secondary amine
• Tertiary alcohol

Synthesis Reference: Not Available

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General Reference: Not Available

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External Links:

Resource	Link

Resource	Link

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ATC Codes:

• Not Available

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AHFS Codes:

• Not Available

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MSDS: Download