Detail

Velaglucerase alfa

Description

Name: Velaglucerase alfa
Type: biotech
Groups: Array
Indication: Velaglucerase alfa is a hydrolytic lysosomal glucocerebroside-specific enzyme indicated for long-term enzyme replacement therapy for pediatric and adult patients with type 1 Gaucher disease.
Accession Number: DB06720 ( DB06720)
Description: Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease.
Structure:
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Vprivinjection, powder, lyophilized, for solution2.5 mg/mLintravenous26-02-2010US
Vprivpowder for solution400 unitintravenous22-11-2010Canada

Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
VprivVelaglucerase alfa
VprivVelaglucerase alfa

Categories
  • Enzymes

Pharmacology

Indication: Velaglucerase alfa is a hydrolytic lysosomal glucocerebroside-specific enzyme indicated for long-term enzyme replacement therapy for pediatric and adult patients with type 1 Gaucher disease.
Pharmacodynamics: Not Available
Mechanism of action: Velaglucerase alfa catalyzes the hydrolysis of glucocerebroside, reducing the amount of accumulated glucocerebroside.
Absorption: Not Available
Volume of distribution:
    The mean volume of distribution at steady state ranges from 82 to 108 mL/kg (8.2% to 10.8% of body weight).

Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: 11-12 minutes.
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
  • Not Available

Dosage forms
FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous2.5 mg/mL
Powder for solutionintravenous400 unit

Prices
Unit descriptionCostUnit

Patents
CountryPatent NumberApprovedExpires (estimated)
7138262United States2006-11-212020-08-18

Interactions

Drug Interactions
DrugInteraction

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic Compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Not Available

substituent:
  • Not Available

References

Synthesis Reference: Not Available
General Reference: # Pastores GM: Velaglucerase alfa, a human recombinant glucocerebrosidase enzyme replacement therapy for type 1 Gaucher disease. Curr Opin Investig Drugs. 2010 Apr;11(4):472-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20336596 # Vairo F, Netto C, Dorneles A, Mittelstadt S, Wilke M, Doneda D, Michelin K, Ribeiro CB, Quevedo A, Vieira T, Nalin T, Lueska S, Schwartz IV: Enzyme Replacement Therapy in a Patient with Gaucher Disease Type III: A Paradigmatic Case Showing Severe Adverse Reactions Started a Long Time After the Beginning of Treatment. JIMD Rep. 2013 Feb 21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23430813
External Links:
ResourceLink
RxListhttp://www.rxlist.com/vpriv-drug.htm
PDRhealthhttp://www.pdrhealth.com/info/v1us/vpriv
Drugs.comhttp://www.drugs.com/vpriv.html3

ATC Codes:
  • Array

AHFS Codes:
  • Not Available

MSDS: Download
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