Detail

Vecuronium

Description

Name: Vecuronium
Type: small molecule
Groups: approved
Indication: Vecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia.
Accession Number: DB01339 ( DB01339)
Description: Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents. [PubChem]
Structure:
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Norcuron Inj 10mg/vialpowder for solution10 mgintravenous31-12-198604-08-2009Canada
Vecuronium Bromide for Injectionpowder for solution10.00 mgintravenous01-06-2000Canada
Vecuronium Bromide for Injectionpowder for solution20.00 mgintravenous28-01-2000Canada
Vecuronium Bromide for Injectionpowder for solution10 mgintravenous13-06-200015-02-2008Canada

Generic Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Vecuroniuminjection, powder, lyophilized, for solution10 mg/10mLintravenous01-08-2011US
Vecuroniuminjection, powder, lyophilized, for solution20 mg/20mLintravenous01-08-2011US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous15-09-2010US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous11-05-2011US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous15-12-2014US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous11-05-2011US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous15-12-2014US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous21-07-2009US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous11-05-2011US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous11-05-2011US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous11-05-2011US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous21-10-1999US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous21-10-1999US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous11-05-2011US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous23-06-2015US
Vecuronium Bromideinjection, powder, lyophilized, for solution1 mg/mLintravenous01-08-2000US
Vecuronium Bromideinjection, powder, lyophilized, for solution10 mg/10mLintravenous25-08-1999US
Vecuronium Bromideinjection, powder, lyophilized, for solution10 mg/10mLintravenous14-11-2002US
Vecuronium Bromideinjection, powder, lyophilized, for solution20 mg/20mLintravenous14-11-2002US
Vecuronium Bromide for Injectioninjection, powder, lyophilized, for solution1 mg/mLintravenous21-07-2009US
Vecuronium Bromide for Injectioninjection, powder, lyophilized, for solution1 mg/mLintravenous21-07-2009US

Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
VecuroniumVecuronium
VecuroniumVecuronium
Vecuronium Bromide for InjectionVecuronium
Vecuronium Bromide for InjectionVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium BromideVecuronium
Vecuronium Bromide for InjectionVecuronium
Vecuronium Bromide for InjectionVecuronium
Vecuronium Bromide for InjectionVecuronium
Norcuron Inj 10mg/vialVecuronium

Categories
  • No Category

Pharmacology

Indication: Vecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia.
Pharmacodynamics: Not Available
Mechanism of action: Vecuronium is a bisquaternary nitrogen compound that acts by competitively binding to nicotinic cholinergic receptors. The binding of vecuronium decreases the opportunity for acetylcholine to bind to the nicotinic receptor at the postjunctional membrane of the myoneural junction. As a result, depolarization is prevented, calcium ions are not released and muscle contraction does not occur.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Fecal (40-75%) and renal (30% as unchanged drug and metabolites)
Half life: 51–80 minutes
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
Dosage forms
FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous1 mg/mL
Injection, powder, lyophilized, for solutionintravenous10 mg/10mL
Injection, powder, lyophilized, for solutionintravenous20 mg/20mL
Powder for solutionintravenous10 mg
Powder for solutionintravenous10.00 mg
Powder for solutionintravenous20.00 mg

Prices
Unit descriptionCostUnit
Vecuronium 10 mg/10 ml syringe$2.36ml
Vecuronium 10 mg vial$3.64vial
Vecuronium 20 mg vial$5.05vial

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction
AmikacinAmikacin may increase the activities of Vecuronium.
AmlodipineAmlodipine may increase the neuromuscular blocking activities of Vecuronium.
AmrinoneAmrinone may increase the neuromuscular blocking activities of Vecuronium.
ArbekacinArbekacin may increase the activities of Vecuronium.
BepridilBepridil may increase the neuromuscular blocking activities of Vecuronium.
Botulinum Toxin Type ABotulinum Toxin Type A may increase the neuromuscular blocking activities of Vecuronium.
Botulinum Toxin Type BVecuronium may increase the neuromuscular blocking activities of Botulinum Toxin Type B.
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Vecuronium.
CarbamazepineThe serum concentration of Vecuronium can be decreased when it is combined with Carbamazepine.
ClindamycinClindamycin may increase the neuromuscular blocking activities of Vecuronium.
ColistimethateColistimethate may increase the neuromuscular blocking activities of Vecuronium.
CyclosporineCyclosporine may increase the neuromuscular blocking activities of Vecuronium.
DantroleneDantrolene may increase the neuromuscular blocking activities of Vecuronium.
DigoxinVecuronium may increase the arrhythmogenic activities of Digoxin.
FelodipineFelodipine may increase the neuromuscular blocking activities of Vecuronium.
FludrocortisoneVecuronium may increase the adverse neuromuscular activities of Fludrocortisone.
FlunarizineFlunarizine may increase the neuromuscular blocking activities of Vecuronium.
FramycetinFramycetin may increase the activities of Vecuronium.
GabapentinGabapentin may increase the neuromuscular blocking activities of Vecuronium.
GentamicinGentamicin may increase the activities of Vecuronium.
IsofluraneIsoflurane may increase the neuromuscular blocking activities of Vecuronium.
IsradipineIsradipine may increase the neuromuscular blocking activities of Vecuronium.
KanamycinKanamycin may increase the activities of Vecuronium.
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Vecuronium.
LamotrigineLamotrigine may increase the neuromuscular blocking activities of Vecuronium.
LercanidipineLercanidipine may increase the neuromuscular blocking activities of Vecuronium.
LincomycinLincomycin may increase the neuromuscular blocking activities of Vecuronium.
LithiumLithium may increase the neuromuscular blocking activities of Vecuronium.
Magnesium SulfateMagnesium Sulfate may increase the neuromuscular blocking activities of Vecuronium.
MinocyclineMinocycline may increase the neuromuscular blocking activities of Vecuronium.
NeomycinNeomycin may increase the activities of Vecuronium.
NetilmicinNetilmicin may increase the activities of Vecuronium.
NicardipineNicardipine may increase the neuromuscular blocking activities of Vecuronium.
NimodipineNimodipine may increase the neuromuscular blocking activities of Vecuronium.
NisoldipineNisoldipine may increase the neuromuscular blocking activities of Vecuronium.
NitrendipineNitrendipine may increase the neuromuscular blocking activities of Vecuronium.
OxytetracyclineOxytetracycline may increase the neuromuscular blocking activities of Vecuronium.
PerhexilinePerhexiline may increase the neuromuscular blocking activities of Vecuronium.
PhenytoinPhenytoin may decrease the neuromuscular blocking activities of Vecuronium.
PiperacillinPiperacillin may increase the neuromuscular blocking activities of Vecuronium.
Polymyxin B SulfatePolymyxin B Sulfate may increase the neuromuscular blocking activities of Vecuronium.
PrenylaminePrenylamine may increase the neuromuscular blocking activities of Vecuronium.
ProcainamideProcainamide may increase the neuromuscular blocking activities of Vecuronium.
QuinidineQuinidine may increase the neuromuscular blocking activities of Vecuronium.
QuinineQuinine may increase the neuromuscular blocking activities of Vecuronium.
RibostamycinRibostamycin may increase the activities of Vecuronium.
RisedronateRisedronate may increase the neuromuscular blocking activities of Vecuronium.
SpectinomycinSpectinomycin may increase the activities of Vecuronium.
SpironolactoneSpironolactone may increase the neuromuscular blocking activities of Vecuronium.
StreptomycinStreptomycin may increase the activities of Vecuronium.
TacrineTacrine may decrease the neuromuscular blocking activities of Vecuronium.
TobramycinTobramycin may increase the activities of Vecuronium.
TorasemideTorasemide may decrease the neuromuscular blocking activities of Vecuronium.
VancomycinVancomycin may increase the neuromuscular blocking activities of Vecuronium.
VerapamilVerapamil may increase the neuromuscular blocking activities of Vecuronium.

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Acetate salts
  • Androstane steroids
  • Azacyclic compounds
  • Carbonyl compounds
  • Carboxylic acid esters
  • Cyclohexylamines
  • Hydrocarbon derivatives
  • Organic cations
  • Piperidines
  • Quaternary ammonium salts
  • Trialkylamines

substituent:
  • Acetate salt
  • Aliphatic heteropolycyclic compound
  • Amine
  • Androstane-skeleton
  • Azacycle
  • Carbonyl group
  • Carboxylic acid derivative
  • Carboxylic acid ester
  • Cyclohexylamine
  • Hydrocarbon derivative
  • Organic cation
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Organooxygen compound
  • Piperidine
  • Quaternary ammonium salt
  • Steroid ester
  • Tertiary aliphatic amine
  • Tertiary amine

References

Synthesis Reference: Frans Herwig Jan Jansen, "Process to prepare pharmaceutical compositions containing vecuronium bromide and compositions produced thereby." U.S. Patent US5681573, issued January, 1969.
General Reference: Not Available
External Links:
ResourceLink
Drugs.comhttp://www.drugs.com/cdi/vecuronium.html

ATC Codes:
  • Array

AHFS Codes:
  • 12:20.00

MSDS: Download
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