Name: Vecuronium

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Type: small molecule

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Groups: approved

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Indication: Vecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia.

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Accession Number: DB01339 ( DB01339)

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Description: Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents. [PubChem]

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Structure:

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Prescription Products:

Name	Dosage	Strength	Route	Marketing Start	Marketing End	Country
Norcuron Inj 10mg/vial	powder for solution	10 mg	intravenous	31-12-1986	04-08-2009	Canada
Vecuronium Bromide for Injection	powder for solution	10.00 mg	intravenous	01-06-2000		Canada
Vecuronium Bromide for Injection	powder for solution	20.00 mg	intravenous	28-01-2000		Canada
Vecuronium Bromide for Injection	powder for solution	10 mg	intravenous	13-06-2000	15-02-2008	Canada

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Generic Prescription Products:

Name	Dosage	Strength	Route	Marketing Start	Marketing End	Country
Vecuronium	injection, powder, lyophilized, for solution	10 mg/10mL	intravenous	01-08-2011		US
Vecuronium	injection, powder, lyophilized, for solution	20 mg/20mL	intravenous	01-08-2011		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	15-09-2010		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	11-05-2011		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	15-12-2014		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	11-05-2011		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	15-12-2014		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	21-07-2009		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	11-05-2011		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	11-05-2011		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	11-05-2011		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	21-10-1999		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	21-10-1999		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	11-05-2011		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	23-06-2015		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	01-08-2000		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	10 mg/10mL	intravenous	25-08-1999		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	10 mg/10mL	intravenous	14-11-2002		US
Vecuronium Bromide	injection, powder, lyophilized, for solution	20 mg/20mL	intravenous	14-11-2002		US
Vecuronium Bromide for Injection	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	21-07-2009		US
Vecuronium Bromide for Injection	injection, powder, lyophilized, for solution	1 mg/mL	intravenous	21-07-2009		US

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Over the Counter Products: Not Available

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International Brands

• No Brands

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Brand Names

• No Brands

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Brand Mixtures

Brand Name	Ingredients
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium	Vecuronium
Vecuronium	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Norcuron Inj 10mg/vial	Vecuronium

Brand Name	Ingredients
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium	Vecuronium
Vecuronium	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Vecuronium Bromide for Injection	Vecuronium
Norcuron Inj 10mg/vial	Vecuronium

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Categories

• No Category

Indication: Vecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia.

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Pharmacodynamics: Not Available

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Mechanism of action: Vecuronium is a bisquaternary nitrogen compound that acts by competitively binding to nicotinic cholinergic receptors. The binding of vecuronium decreases the opportunity for acetylcholine to bind to the nicotinic receptor at the postjunctional membrane of the myoneural junction. As a result, depolarization is prevented, calcium ions are not released and muscle contraction does not occur.

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Absorption: Not Available

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Volume of distribution: Not Available

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Protein binding: Not Available

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Metabolism: Not Available

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Route of elimination: Fecal (40-75%) and renal (30% as unchanged drug and metabolites)

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Half life: 51–80 minutes

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Clearance: Not Available

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Toxicity: Not Available

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Affected organisms

• Not Available

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SNP Mediated Adverse Drug Reactions

• Not Available

Manufacturers:

• Not Available

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Packagers:

• APP Pharmaceuticals
• Baxter International Inc.
• Bedford Labs
• Ben Venue Laboratories Inc.
• Cardinal Health
• Hospira Inc.
• Organon Pharmaceuticals
• Pharmedium
• Schein Pharmaceutical Inc.
• Sun Pharmaceutical Industries Ltd.
• Teva Pharmaceutical Industries Ltd.
• Watson Pharmaceuticals
• Zhejiang Xianju Pharmaceutical Co. Ltd.

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Dosage forms

Form	Route	Strength
Injection, powder, lyophilized, for solution	intravenous	1 mg/mL
Injection, powder, lyophilized, for solution	intravenous	10 mg/10mL
Injection, powder, lyophilized, for solution	intravenous	20 mg/20mL
Powder for solution	intravenous	10 mg
Powder for solution	intravenous	10.00 mg
Powder for solution	intravenous	20.00 mg

Form	Route	Strength
Injection, powder, lyophilized, for solution	intravenous	1 mg/mL
Injection, powder, lyophilized, for solution	intravenous	10 mg/10mL
Injection, powder, lyophilized, for solution	intravenous	20 mg/20mL
Powder for solution	intravenous	10 mg
Powder for solution	intravenous	10.00 mg
Powder for solution	intravenous	20.00 mg

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Prices

Unit description	Cost	Unit
Vecuronium 10 mg/10 ml syringe	$2.36	ml
Vecuronium 10 mg vial	$3.64	vial
Vecuronium 20 mg vial	$5.05	vial

Unit description	Cost	Unit
Vecuronium 10 mg/10 ml syringe	$2.36	ml
Vecuronium 10 mg vial	$3.64	vial
Vecuronium 20 mg vial	$5.05	vial

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Patents

Country	Patent Number	Approved	Expires (estimated)

Drug Interactions

Drug	Interaction
Amikacin	Amikacin may increase the activities of Vecuronium.
Amlodipine	Amlodipine may increase the neuromuscular blocking activities of Vecuronium.
Amrinone	Amrinone may increase the neuromuscular blocking activities of Vecuronium.
Arbekacin	Arbekacin may increase the activities of Vecuronium.
Bepridil	Bepridil may increase the neuromuscular blocking activities of Vecuronium.
Botulinum Toxin Type A	Botulinum Toxin Type A may increase the neuromuscular blocking activities of Vecuronium.
Botulinum Toxin Type B	Vecuronium may increase the neuromuscular blocking activities of Botulinum Toxin Type B.
Capreomycin	Capreomycin may increase the neuromuscular blocking activities of Vecuronium.
Carbamazepine	The serum concentration of Vecuronium can be decreased when it is combined with Carbamazepine.
Clindamycin	Clindamycin may increase the neuromuscular blocking activities of Vecuronium.
Colistimethate	Colistimethate may increase the neuromuscular blocking activities of Vecuronium.
Cyclosporine	Cyclosporine may increase the neuromuscular blocking activities of Vecuronium.
Dantrolene	Dantrolene may increase the neuromuscular blocking activities of Vecuronium.
Digoxin	Vecuronium may increase the arrhythmogenic activities of Digoxin.
Felodipine	Felodipine may increase the neuromuscular blocking activities of Vecuronium.
Fludrocortisone	Vecuronium may increase the adverse neuromuscular activities of Fludrocortisone.
Flunarizine	Flunarizine may increase the neuromuscular blocking activities of Vecuronium.
Framycetin	Framycetin may increase the activities of Vecuronium.
Gabapentin	Gabapentin may increase the neuromuscular blocking activities of Vecuronium.
Gentamicin	Gentamicin may increase the activities of Vecuronium.
Isoflurane	Isoflurane may increase the neuromuscular blocking activities of Vecuronium.
Isradipine	Isradipine may increase the neuromuscular blocking activities of Vecuronium.
Kanamycin	Kanamycin may increase the activities of Vecuronium.
Ketorolac	The risk or severity of adverse effects can be increased when Ketorolac is combined with Vecuronium.
Lamotrigine	Lamotrigine may increase the neuromuscular blocking activities of Vecuronium.
Lercanidipine	Lercanidipine may increase the neuromuscular blocking activities of Vecuronium.
Lincomycin	Lincomycin may increase the neuromuscular blocking activities of Vecuronium.
Lithium	Lithium may increase the neuromuscular blocking activities of Vecuronium.
Magnesium Sulfate	Magnesium Sulfate may increase the neuromuscular blocking activities of Vecuronium.
Minocycline	Minocycline may increase the neuromuscular blocking activities of Vecuronium.
Neomycin	Neomycin may increase the activities of Vecuronium.
Netilmicin	Netilmicin may increase the activities of Vecuronium.
Nicardipine	Nicardipine may increase the neuromuscular blocking activities of Vecuronium.
Nimodipine	Nimodipine may increase the neuromuscular blocking activities of Vecuronium.
Nisoldipine	Nisoldipine may increase the neuromuscular blocking activities of Vecuronium.
Nitrendipine	Nitrendipine may increase the neuromuscular blocking activities of Vecuronium.
Oxytetracycline	Oxytetracycline may increase the neuromuscular blocking activities of Vecuronium.
Perhexiline	Perhexiline may increase the neuromuscular blocking activities of Vecuronium.
Phenytoin	Phenytoin may decrease the neuromuscular blocking activities of Vecuronium.
Piperacillin	Piperacillin may increase the neuromuscular blocking activities of Vecuronium.
Polymyxin B Sulfate	Polymyxin B Sulfate may increase the neuromuscular blocking activities of Vecuronium.
Prenylamine	Prenylamine may increase the neuromuscular blocking activities of Vecuronium.
Procainamide	Procainamide may increase the neuromuscular blocking activities of Vecuronium.
Quinidine	Quinidine may increase the neuromuscular blocking activities of Vecuronium.
Quinine	Quinine may increase the neuromuscular blocking activities of Vecuronium.
Ribostamycin	Ribostamycin may increase the activities of Vecuronium.
Risedronate	Risedronate may increase the neuromuscular blocking activities of Vecuronium.
Spectinomycin	Spectinomycin may increase the activities of Vecuronium.
Spironolactone	Spironolactone may increase the neuromuscular blocking activities of Vecuronium.
Streptomycin	Streptomycin may increase the activities of Vecuronium.
Tacrine	Tacrine may decrease the neuromuscular blocking activities of Vecuronium.
Tobramycin	Tobramycin may increase the activities of Vecuronium.
Torasemide	Torasemide may decrease the neuromuscular blocking activities of Vecuronium.
Vancomycin	Vancomycin may increase the neuromuscular blocking activities of Vecuronium.
Verapamil	Verapamil may increase the neuromuscular blocking activities of Vecuronium.

Drug	Interaction
Amikacin	Amikacin may increase the activities of Vecuronium.
Amlodipine	Amlodipine may increase the neuromuscular blocking activities of Vecuronium.
Amrinone	Amrinone may increase the neuromuscular blocking activities of Vecuronium.
Arbekacin	Arbekacin may increase the activities of Vecuronium.
Bepridil	Bepridil may increase the neuromuscular blocking activities of Vecuronium.
Botulinum Toxin Type A	Botulinum Toxin Type A may increase the neuromuscular blocking activities of Vecuronium.
Botulinum Toxin Type B	Vecuronium may increase the neuromuscular blocking activities of Botulinum Toxin Type B.
Capreomycin	Capreomycin may increase the neuromuscular blocking activities of Vecuronium.
Carbamazepine	The serum concentration of Vecuronium can be decreased when it is combined with Carbamazepine.
Clindamycin	Clindamycin may increase the neuromuscular blocking activities of Vecuronium.
Colistimethate	Colistimethate may increase the neuromuscular blocking activities of Vecuronium.
Cyclosporine	Cyclosporine may increase the neuromuscular blocking activities of Vecuronium.
Dantrolene	Dantrolene may increase the neuromuscular blocking activities of Vecuronium.
Digoxin	Vecuronium may increase the arrhythmogenic activities of Digoxin.
Felodipine	Felodipine may increase the neuromuscular blocking activities of Vecuronium.
Fludrocortisone	Vecuronium may increase the adverse neuromuscular activities of Fludrocortisone.
Flunarizine	Flunarizine may increase the neuromuscular blocking activities of Vecuronium.
Framycetin	Framycetin may increase the activities of Vecuronium.
Gabapentin	Gabapentin may increase the neuromuscular blocking activities of Vecuronium.
Gentamicin	Gentamicin may increase the activities of Vecuronium.
Isoflurane	Isoflurane may increase the neuromuscular blocking activities of Vecuronium.
Isradipine	Isradipine may increase the neuromuscular blocking activities of Vecuronium.
Kanamycin	Kanamycin may increase the activities of Vecuronium.
Ketorolac	The risk or severity of adverse effects can be increased when Ketorolac is combined with Vecuronium.
Lamotrigine	Lamotrigine may increase the neuromuscular blocking activities of Vecuronium.
Lercanidipine	Lercanidipine may increase the neuromuscular blocking activities of Vecuronium.
Lincomycin	Lincomycin may increase the neuromuscular blocking activities of Vecuronium.
Lithium	Lithium may increase the neuromuscular blocking activities of Vecuronium.
Magnesium Sulfate	Magnesium Sulfate may increase the neuromuscular blocking activities of Vecuronium.
Minocycline	Minocycline may increase the neuromuscular blocking activities of Vecuronium.
Neomycin	Neomycin may increase the activities of Vecuronium.
Netilmicin	Netilmicin may increase the activities of Vecuronium.
Nicardipine	Nicardipine may increase the neuromuscular blocking activities of Vecuronium.
Nimodipine	Nimodipine may increase the neuromuscular blocking activities of Vecuronium.
Nisoldipine	Nisoldipine may increase the neuromuscular blocking activities of Vecuronium.
Nitrendipine	Nitrendipine may increase the neuromuscular blocking activities of Vecuronium.
Oxytetracycline	Oxytetracycline may increase the neuromuscular blocking activities of Vecuronium.
Perhexiline	Perhexiline may increase the neuromuscular blocking activities of Vecuronium.
Phenytoin	Phenytoin may decrease the neuromuscular blocking activities of Vecuronium.
Piperacillin	Piperacillin may increase the neuromuscular blocking activities of Vecuronium.
Polymyxin B Sulfate	Polymyxin B Sulfate may increase the neuromuscular blocking activities of Vecuronium.
Prenylamine	Prenylamine may increase the neuromuscular blocking activities of Vecuronium.
Procainamide	Procainamide may increase the neuromuscular blocking activities of Vecuronium.
Quinidine	Quinidine may increase the neuromuscular blocking activities of Vecuronium.
Quinine	Quinine may increase the neuromuscular blocking activities of Vecuronium.
Ribostamycin	Ribostamycin may increase the activities of Vecuronium.
Risedronate	Risedronate may increase the neuromuscular blocking activities of Vecuronium.
Spectinomycin	Spectinomycin may increase the activities of Vecuronium.
Spironolactone	Spironolactone may increase the neuromuscular blocking activities of Vecuronium.
Streptomycin	Streptomycin may increase the activities of Vecuronium.
Tacrine	Tacrine may decrease the neuromuscular blocking activities of Vecuronium.
Tobramycin	Tobramycin may increase the activities of Vecuronium.
Torasemide	Torasemide may decrease the neuromuscular blocking activities of Vecuronium.
Vancomycin	Vancomycin may increase the neuromuscular blocking activities of Vecuronium.
Verapamil	Verapamil may increase the neuromuscular blocking activities of Vecuronium.

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Food Interactions:

• Not Available

Kingdom: Organic compounds

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Super Class: Not Available

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Class: Not Available

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Sub Class: Not Available

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Direct Parent: Not Available

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Alternative Parents:

• Acetate salts
• Androstane steroids
• Azacyclic compounds
• Carbonyl compounds
• Carboxylic acid esters
• Cyclohexylamines
• Hydrocarbon derivatives
• Organic cations
• Piperidines
• Quaternary ammonium salts
• Trialkylamines

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substituent:

• Acetate salt
• Aliphatic heteropolycyclic compound
• Amine
• Androstane-skeleton
• Azacycle
• Carbonyl group
• Carboxylic acid derivative
• Carboxylic acid ester
• Cyclohexylamine
• Hydrocarbon derivative
• Organic cation
• Organoheterocyclic compound
• Organonitrogen compound
• Organooxygen compound
• Piperidine
• Quaternary ammonium salt
• Steroid ester
• Tertiary aliphatic amine
• Tertiary amine

Synthesis Reference: Frans Herwig Jan Jansen, "Process to prepare pharmaceutical compositions containing vecuronium bromide and compositions produced thereby." U.S. Patent US5681573, issued January, 1969.

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General Reference: Not Available

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External Links:

Resource	Link
Drugs.com	http://www.drugs.com/cdi/vecuronium.html

Resource	Link
Drugs.com	http://www.drugs.com/cdi/vecuronium.html

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ATC Codes:

• Array

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AHFS Codes:

• 12:20.00

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MSDS: Download