Name: Vasopressin
Type: biotech
Groups: approved
Indication: For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Accession Number: DB00067 ( BIOD00110, BTD00110)
Description: Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Pitressininjection20 [USP'U]/mLintramuscular; subcutaneous01-10-2007US
Pitressin Inj 10 Unit/0.5mlliquid10 unitintramuscular; subcutaneous31-12-197125-08-1997Canada
Pressyn Arliquid20 unitintramuscular; subcutaneous04-11-2002Canada
Vasopressininjection, solution20 [USP'U]/mLintramuscular; subcutaneous15-08-1996US
Vasopressininjection, solution20 [USP'U]/mLintramuscular; subcutaneous01-10-1992US
Vasopressininjection, solution20 [USP'U]/mLintramuscular; subcutaneous01-08-2010US
Vasopressininjection, solution20 [USP'U]/mLintramuscular; subcutaneous01-10-1992US
Vasopressininjection, solution20 [USP'U]/mLintramuscular; subcutaneous01-03-2010US
Vasopressininjection, solution20 [USP'U]/mLintramuscular; subcutaneous17-07-2001US
Vasopressininjection, solution20 [USP'U]/mLintramuscular; subcutaneous17-12-2013US
Vasopressininjection20 [USP'U]/mLintramuscular17-10-2011US
Vasopressin Inj 20unit/ml USPliquid20 unitintramuscular; nasal; subcutaneous31-12-198822-07-2015Canada
Vasopressin Inj 20unit/ml USPliquid20 unitintramuscular; subcutaneous31-12-199210-09-1996Canada
Vasopressin Injectionsolution20 unitintramuscular; subcutaneous14-08-1996Canada
Vasopressin Injection USPsolution20 unitintramuscular; subcutaneous10-12-2003Canada

Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
Pressyn ArVasopressin
Vasopressin Injection USPVasopressin
Pitressin Inj 10 Unit/0.5mlVasopressin
Vasopressin Inj 20unit/ml USPVasopressin
Vasopressin Inj 20unit/ml USPVasopressin
Vasopressin InjectionVasopressin

  • Antidiuretic Agents


Indication: For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Pharmacodynamics: Not Available
Mechanism of action: Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: 1%
Metabolism: Not Available
Route of elimination: Not Available
Half life: 10-20 minutes
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available


  • Parke davis div warner lambert co

Dosage forms
Injectionintramuscular; subcutaneous20 [USP'U]/mL
Liquidintramuscular; subcutaneous10 unit
Liquidintramuscular; subcutaneous20 unit
Injectionintramuscular20 [USP'U]/mL
Injection, solutionintramuscular; subcutaneous20 [USP'U]/mL
Liquidintramuscular; nasal; subcutaneous20 unit
Solutionintramuscular; subcutaneous20 unit

Unit descriptionCostUnit
Vasopressin 20 unit/ml vial$1.86ml
Vasopressin 10 unit/0.5 ml vial$2.88vial
Pitressin 20 unit/ml vial$7.68ml

CountryPatent NumberApprovedExpires (estimated)


Drug Interactions

Food Interactions:
  • Ethanol


Kingdom: Organic Compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Not Available

  • Not Available


Synthesis Reference: Nedumparambil A. Abraham, Hans U. Immer, Kazimir Sestanj, "Process for producing triglycyl-lysine vasopressin and intermediates therefor." U.S. Patent US4093610, issued June, 1963.
General Reference: # Bielsky IF, Hu SB, Szegda KL, Westphal H, Young LJ: Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology. 2004 Mar;29(3):483-93. "Pubmed": # Wersinger SR, Caldwell HK, Martinez L, Gold P, Hu SB, Young WS 3rd: Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes Brain Behav. 2007 Aug;6(6):540-51. Epub 2006 Nov 3. "Pubmed": # Lolait SJ, Stewart LQ, Jessop DS, Young WS 3rd, O'Carroll AM: The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Endocrinology. 2007 Feb;148(2):849-56. Epub 2006 Nov 22. "Pubmed": # Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS 3rd: Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Horm Behav. 2004 Dec;46(5):638-45. "Pubmed": # Kanwar S, Woodman RC, Poon MC, Murohara T, Lefer AM, Davenpeck KL, Kubes P: Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules. Blood. 1995 Oct 1;86(7):2760-6. "Pubmed":
External Links:

ATC Codes:
  • Array

AHFS Codes:
  • 68:28.00

MSDS: Download

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