Detail

Vancomycin

Description

Name: Vancomycin
Type: small molecule
Groups: approved
Indication: For the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci.
Accession Number: DB00512 ( APRD01287, EXPT03217)
Description: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. [PubChem]
Structure:
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Jamp-vancomycinpowder for solution500 mgintravenous22-09-2014Canada
Jamp-vancomycinpowder for solution1 gintravenous22-09-2014Canada
Jamp-vancomycinpowder for solution5 gintravenous22-09-2014Canada
Jamp-vancomycinpowder for solution10 gintravenous06-06-2014Canada
Jamp-vancomycincapsule125 mgoral26-03-2014Canada
Jamp-vancomycincapsule250 mgoral26-03-2014Canada
Mylan-vancomycin Hydrochloride for Injection, USPpowder for solution500 mgintravenous01-01-1970Canada
Mylan-vancomycin Hydrochloride for Injection, USPpowder for solution1 gintravenous01-01-1970Canada
Mylan-vancomycin Hydrochloride for Injection, USPpowder for solution5 gintravenous01-01-1970Canada
Mylan-vancomycin Hydrochloride for Injection, USPpowder for solution10 gintravenous01-01-1970Canada
PMS-vancomycincapsule125 mgoral01-01-1970Canada
PMS-vancomycincapsule250 mgoral18-03-2015Canada
PMS-vancomycin 1 Gpowder for solution1.0 gintravenous30-10-2000Canada
PMS-vancomycin 500 mgpowder for solution500 mgintravenous30-10-2000Canada
Sterile Vancomycin HCl 5.0gm/vialpowder for solution5 gintravenous31-12-199210-09-1996Canada
Sterile Vancomycin HCl USP 1.0gm/vialpowder for solution1 gintravenous31-12-199210-09-1996Canada
Sterile Vancomycin HCl USP 500mg/vialpowder for solution500 mgintravenous31-12-199210-09-1996Canada
Sterile Vancomycin Hydrochloride, USPpowder for solution1 gintravenous31-12-198715-02-2008Canada
Sterile Vancomycin Hydrochloride, USPpowder for solution500 mgintravenous31-12-195915-02-2008Canada
Val-vancomycinpowder for solution1 gintravenous23-09-2010Canada
Val-vancomycinpowder for solution10 gintravenous12-06-2013Canada
Val-vancomycinpowder for solution5 gintravenous01-01-1970Canada
Val-vancomycinpowder for solution500 mgintravenous23-09-2010Canada
Vancocincapsule125 mg/1oral15-04-1986US
Vancocincapsule250 mg/1oral15-04-1986US
Vancocincapsule125 mg/1oral15-04-1986US
Vancocincapsule250 mg/1oral15-04-1986US
Vancocincapsule250 mgoral31-12-1989Canada
Vancocincapsule125 mgoral31-12-1989Canada
Vancocincapsule125 mg/1oral17-11-2014US
Vancocincapsule250 mg/1oral17-11-2014US
Vancocin Cp Add-vantage Inj 500mg/vialpowder for solution500 mgintravenous31-12-198926-07-2002Canada
Vancocin Inj 1gm/vial Advantagepowder1 gintravenous31-12-198926-07-2002Canada
Vancomycin HClinjection, solution4.2 mg/mLintravenous01-05-2013US
Vancomycin HClinjection, solution5 mg/mLintravenous25-05-2012US
Vancomycin HClinjection, solution6 mg/mLintravenous25-05-2012US
Vancomycin Hydrochloridecapsule125 mg/1oral10-04-2012US
Vancomycin Hydrochloridecapsule250 mg/1oral10-04-2012US
Vancomycin Hydrochlorideinjection, solution500 mg/100mLintravenous18-12-2015US
Vancomycin Hydrochlorideinjection, solution750 mg/150mLintravenous18-12-2015US
Vancomycin Hydrochlorideinjection, solution1 g/200mLintravenous18-12-2015US
Vancomycin Hydrochlorideinjection, solution500 mg/100mLintravenous14-11-1958US
Vancomycin Hydrochlorideinjection, solution1 g/200mLintravenous14-11-1958US
Vancomycin Hydrochlorideinjection, solution750 mg/150mLintravenous14-11-1958US
Vancomycin Hydrochloridecapsule125 mg/1oral26-10-2015US
Vancomycin Hydrochloridecapsule250 mg/1oral26-10-2015US
Vancomycin Hydrochloride Capsules, USPcapsule125 mgoral01-01-1970Canada
Vancomycin Hydrochloride Capsules, USPcapsule250 mgoral01-01-1970Canada
Vancomycin Hydrochloride Capsules, USPcapsule125 mgoral16-07-2012Canada
Vancomycin Hydrochloride Capsules, USPcapsule250 mgoral16-07-2012Canada
Vancomycin Hydrochloride for Injectionpowder for solution1000 mgintravenous30-01-2013Canada
Vancomycin Hydrochloride for Injectionpowder for solution500 mgintravenous30-09-2013Canada
Vancomycin Hydrochloride for Injectionpowder for solution10 gintravenous30-09-2013Canada
Vancomycin Hydrochloride for Injection USPpowder for solution500 mgintravenous01-01-1970Canada
Vancomycin Hydrochloride for Injection USPpowder for solution1000 mgintravenous01-01-1970Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution5 gintravenous14-08-1996Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution5 gintravenous17-11-2015Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution10 gintravenous05-10-2015Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution10 gintravenous10-07-2000Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution500 mgintravenous10-03-2014Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution1 gintravenous10-03-2014Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution500 mgintravenous18-03-2014Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution5 gintravenous28-12-2013Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution1 gintravenous18-03-2014Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution5 gintravenous14-02-2013Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution10 gintravenous14-02-2013Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution10 gintravenous01-01-1970Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution500 mgintravenous31-03-2000Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution1000 mgintravenous31-03-2000Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution10 gintravenous31-12-199315-02-2008Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution500 mgintravenous31-12-1992Canada
Vancomycin Hydrochloride for Injection, USPpowder for solution1 gintravenous31-12-1992Canada

Generic Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Sterile Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous31-12-2008US
Sterile Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous31-12-2008US
Sterile Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution5 g/100mLintravenous31-12-2008US
Sterile Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous01-09-2010US
Sterile Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution5 g/100mLintravenous10-05-2011US
Sterile Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous31-12-2008US
Vancomycininjection, powder, lyophilized, for solution5 g/100mLintravenous20-09-2012US
Vancomycininjection, powder, lyophilized, for solution10 g/100mLintravenous20-09-2012US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous04-08-1988US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous21-12-1990US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution100 mg/mLintravenous29-04-2009US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution750 mg/250mLintravenous04-08-1988US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous04-08-1988US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/100mLintravenous29-10-1992US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/250mLintravenous29-10-1992US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous01-09-2000US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous20-09-2000US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution5 g/100mLintravenous17-07-2001US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous31-12-2008US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous31-12-2008US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution5 g/100mLintravenous31-12-2008US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution10 g/100mLintravenous19-09-2011US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution10 g/100mLintravenous30-11-2004US
Vancomycin Hydrochloridecapsule125 mg/1oral09-04-2012US
Vancomycin Hydrochloridecapsule250 mg/1oral09-04-2012US
Vancomycin Hydrochloridecapsule125 mg/1oral18-06-2012US
Vancomycin Hydrochloridecapsule250 mg/1oral18-06-2012US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous27-04-2010US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous27-04-2010US
Vancomycin Hydrochlorideinjection5 g/100mLintravenous10-02-2015US
Vancomycin Hydrochlorideinjection10 g/100mLintravenous10-02-2015US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/1intravenous10-04-2014US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution10 g/100mLintravenous02-07-2011US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/1intravenous10-04-2014US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous10-05-2011US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous10-05-2011US
Vancomycin Hydrochloridecapsule125 mg/1oral27-03-2015US
Vancomycin Hydrochloridecapsule250 mg/1oral27-03-2015US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution10 g/100mLintravenous10-05-2011US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution10 g/100mLintravenous19-09-2011US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/250mLintravenous29-07-2010US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous30-06-2008US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/4mLintravenous15-11-2013US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/100mLintravenous29-07-2010US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/8mLintravenous15-11-2013US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous10-01-2012US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution5 g/100mLintravenous25-11-2011US
Vancomycin Hydrochloridecapsule125 mg/1oral09-04-2012US
Vancomycin Hydrochloridecapsule250 mg/1oral09-04-2012US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/250mLintravenous29-07-2010US
Vancomycin Hydrochloridecapsule125 mg/1oral09-04-2012US
Vancomycin Hydrochloridecapsule250 mg/1oral09-04-2012US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous31-12-2008US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous04-06-2010US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution1 g/20mLintravenous31-12-2008US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution5 g/100mLintravenous31-12-2008US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution10 g/100mLintravenous19-09-2011US
Vancomycin Hydrochlorideinjection, powder, lyophilized, for solution500 mg/10mLintravenous04-06-2010US
Vancomycin Hydroclorideinjection, powder, lyophilized, for solution10 g/80mLintravenous29-11-2011US

Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Sterile Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Sterile Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydroclorideVancomycin
Sterile Vancomycin HydrochlorideVancomycin
Sterile Vancomycin HydrochlorideVancomycin
Sterile Vancomycin HydrochlorideVancomycin
VancomycinVancomycin
VancomycinVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HClVancomycin
Vancomycin HClVancomycin
Vancomycin HClVancomycin
Sterile Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
VancocinVancomycin
VancocinVancomycin
VancocinVancomycin
VancocinVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
VancocinVancomycin
VancocinVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
PMS-vancomycin 500 mgVancomycin
PMS-vancomycin 1 GVancomycin
Val-vancomycinVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for InjectionVancomycin
Val-vancomycinVancomycin
Jamp-vancomycinVancomycin
Jamp-vancomycinVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for InjectionVancomycin
Vancomycin Hydrochloride for InjectionVancomycin
Jamp-vancomycinVancomycin
Jamp-vancomycinVancomycin
Jamp-vancomycinVancomycin
Jamp-vancomycinVancomycin
PMS-vancomycinVancomycin
VancocinVancomycin
VancocinVancomycin
Sterile Vancomycin HCl USP 1.0gm/vialVancomycin
Sterile Vancomycin HCl USP 500mg/vialVancomycin
Sterile Vancomycin HCl 5.0gm/vialVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Sterile Vancomycin Hydrochloride, USPVancomycin
Sterile Vancomycin Hydrochloride, USPVancomycin
Vancocin Cp Add-vantage Inj 500mg/vialVancomycin
Vancocin Inj 1gm/vial AdvantageVancomycin
Val-vancomycinVancomycin
Vancomycin Hydrochloride Capsules, USPVancomycin
Vancomycin Hydrochloride Capsules, USPVancomycin
Mylan-vancomycin Hydrochloride for Injection, USPVancomycin
Mylan-vancomycin Hydrochloride for Injection, USPVancomycin
Mylan-vancomycin Hydrochloride for Injection, USPVancomycin
Mylan-vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
PMS-vancomycinVancomycin
Vancomycin Hydrochloride for Injection USPVancomycin
Vancomycin Hydrochloride for Injection USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Val-vancomycinVancomycin
Vancomycin Hydrochloride Capsules, USPVancomycin
Vancomycin Hydrochloride Capsules, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin Hydrochloride for Injection, USPVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin
Vancomycin HydrochlorideVancomycin

Categories
  • Anti-Bacterial Agents

Pharmacology

Indication: For the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci.
Pharmacodynamics: Not Available
Mechanism of action: The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix; which forms the major structural component of Gram-positive cell walls. The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Normally this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents the incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix. In addition, vancomycin alters bacterial-cell-membrane permeability and RNA synthesis. There is no cross-resistance between vancomycin and other antibiotics. Vancomycin is not active in vitro against gram-negative bacilli, mycobacteria, or fungi.
Absorption: Poorly absorbed from gastrointestinal tract, however systemic absorption (up to 60%) may occur following intraperitoneal administration.
Volume of distribution: Not Available
Protein binding: Approximately 55% serum protein bound.
Metabolism: Not Available
Route of elimination: In the first 24 hours, about 75% of an administered dose of vancomycin is excreted in urine by glomerular filtration.
Half life: Half-life in normal renal patients is approximately 6 hours (range 4 to 11 hours). In anephric patients, the average half-life of elimination is 7.5 days.
Clearance: Not Available
Toxicity: The oral LD50 in mice is 5000 mg/kg. The median lethal intravenous dose is 319 mg/kg in rats and 400 mg/kg in mice.
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Viropharma inc
  • Lederle parenterals inc
  • Baxter healthcare corp
  • Baxter healthcare corp anesthesia and critical care
  • Akorn strides llc
  • App pharmaceuticals llc
  • Bioniche pharma usa llc
  • Hospira inc
  • Sandoz inc
  • Pharmacia and upjohn co

Packagers:
Dosage forms
FormRouteStrength
Capsuleoral125 mg
Capsuleoral250 mg
Powder for solutionintravenous1.0 g
Powder for solutionintravenous500 mg
Injection, powder, lyophilized, for solutionintravenous5 g/100mL
Powder for solutionintravenous1 g
Powderintravenous1 g
Injection, solutionintravenous4.2 mg/mL
Injection, solutionintravenous5 mg/mL
Injection, solutionintravenous6 mg/mL
Capsuleoral125 mg/1
Capsuleoral250 mg/1
Injectionintravenous10 g/100mL
Injectionintravenous5 g/100mL
Injection, powder, lyophilized, for solutionintravenous1 g/8mL
Injection, powder, lyophilized, for solutionintravenous1 g/250mL
Injection, powder, lyophilized, for solutionintravenous1 g/1
Injection, powder, lyophilized, for solutionintravenous1 g/20mL
Injection, powder, lyophilized, for solutionintravenous10 g/100mL
Injection, powder, lyophilized, for solutionintravenous100 mg/mL
Injection, powder, lyophilized, for solutionintravenous500 mg/10mL
Injection, powder, lyophilized, for solutionintravenous500 mg/4mL
Injection, powder, lyophilized, for solutionintravenous500 mg/100mL
Injection, powder, lyophilized, for solutionintravenous500 mg/1
Injection, powder, lyophilized, for solutionintravenous750 mg/250mL
Injection, solutionintravenous1 g/200mL
Injection, solutionintravenous500 mg/100mL
Injection, solutionintravenous750 mg/150mL
Powder for solutionintravenous1000 mg
Powder for solutionintravenous10 g
Powder for solutionintravenous5 g
Injection, powder, lyophilized, for solutionintravenous10 g/80mL

Prices
Unit descriptionCostUnit
Vancomycin 500 mg vial$3.74vial
Vancomycin hcl 750 mg vial$5.72vial
Vancomycin 1 gm vial$7.0vial
Vancocin hcl 125 mg pulvule$22.22each
Vancocin HCl 125 mg capsule$27.66capsule
Pms-Vancomycin 500 mg/vial$32.62vial
Vancocin hcl 250 mg pulvule$40.97each
Pms-Vancomycin 1 g/vial$61.98vial
Vancomycin hcl powder$85.68g
Vancocin HCl 20 250 mg capsule Box$1019.87box
Vancomycin hcl 1 g/200 ml bag$0.17ml
Vancomycin-ns 1.25 g/150 ml$0.21ml
Vancomycin-ns 1.5 g/150 ml$0.24ml

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction
AmikacinVancomycin may increase the nephrotoxic activities of Amikacin.
ArbekacinVancomycin may increase the nephrotoxic activities of Arbekacin.
Atracurium besylateVancomycin may increase the neuromuscular blocking activities of Atracurium besylate.
CelecoxibThe serum concentration of Vancomycin can be increased when it is combined with Celecoxib.
CholestyramineThe therapeutic efficacy of Vancomycin can be decreased when used in combination with Cholestyramine.
Cisatracurium besylateVancomycin may increase the neuromuscular blocking activities of Cisatracurium besylate.
ColesevelamThe therapeutic efficacy of Vancomycin can be decreased when used in combination with Colesevelam.
ColestipolThe therapeutic efficacy of Vancomycin can be decreased when used in combination with Colestipol.
ColistimethateVancomycin may increase the nephrotoxic activities of Colistimethate.
ColistinVancomycin may increase the nephrotoxic activities of Colistin.
DiclofenacThe serum concentration of Vancomycin can be increased when it is combined with Diclofenac.
DiflunisalThe serum concentration of Vancomycin can be increased when it is combined with Diflunisal.
EtodolacThe serum concentration of Vancomycin can be increased when it is combined with Etodolac.
FenoprofenThe serum concentration of Vancomycin can be increased when it is combined with Fenoprofen.
FloctafenineThe serum concentration of Vancomycin can be increased when it is combined with Floctafenine.
FlurbiprofenThe serum concentration of Vancomycin can be increased when it is combined with Flurbiprofen.
FramycetinVancomycin may increase the nephrotoxic activities of Framycetin.
GentamicinVancomycin may increase the nephrotoxic activities of Gentamicin.
IbuprofenThe serum concentration of Vancomycin can be increased when it is combined with Ibuprofen.
IndomethacinThe serum concentration of Vancomycin can be increased when it is combined with Indomethacin.
InfliximabThe serum concentration of Vancomycin can be increased when it is combined with Infliximab.
KanamycinVancomycin may increase the nephrotoxic activities of Kanamycin.
KetoprofenThe serum concentration of Vancomycin can be increased when it is combined with Ketoprofen.
KetorolacThe serum concentration of Vancomycin can be increased when it is combined with Ketorolac.
Mefenamic acidThe serum concentration of Vancomycin can be increased when it is combined with Mefenamic acid.
MeloxicamThe serum concentration of Vancomycin can be increased when it is combined with Meloxicam.
NabumetoneThe serum concentration of Vancomycin can be increased when it is combined with Nabumetone.
NaproxenThe serum concentration of Vancomycin can be increased when it is combined with Naproxen.
NeomycinVancomycin may increase the nephrotoxic activities of Neomycin.
NetilmicinVancomycin may increase the nephrotoxic activities of Netilmicin.
OxaprozinThe serum concentration of Vancomycin can be increased when it is combined with Oxaprozin.
PancuroniumVancomycin may increase the neuromuscular blocking activities of Pancuronium.
PiperacillinPiperacillin may increase the nephrotoxic activities of Vancomycin.
PiroxicamThe serum concentration of Vancomycin can be increased when it is combined with Piroxicam.
RibostamycinVancomycin may increase the nephrotoxic activities of Ribostamycin.
RocuroniumVancomycin may increase the neuromuscular blocking activities of Rocuronium.
Sodium picosulfateThe therapeutic efficacy of Sodium picosulfate can be decreased when used in combination with Vancomycin.
SpectinomycinVancomycin may increase the nephrotoxic activities of Spectinomycin.
StreptomycinVancomycin may increase the nephrotoxic activities of Streptomycin.
SuccinylcholineVancomycin may increase the neuromuscular blocking activities of Succinylcholine.
SulindacThe serum concentration of Vancomycin can be increased when it is combined with Sulindac.
Tiaprofenic acidThe serum concentration of Vancomycin can be increased when it is combined with Tiaprofenic acid.
TobramycinVancomycin may increase the nephrotoxic activities of Tobramycin.
TolmetinThe serum concentration of Vancomycin can be increased when it is combined with Tolmetin.
VecuroniumVancomycin may increase the neuromuscular blocking activities of Vecuronium.

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • 1,2-aminoalcohols
  • 1,2-diols
  • Acetals
  • Alpha amino acid amides
  • Amino sugars
  • Aryl chlorides
  • Azacyclic compounds
  • Carbonyl compounds
  • Carboxylic acids
  • Dialkylamines
  • Diarylethers
  • Disaccharides
  • Hydrocarbon derivatives
  • Lactams
  • Monoalkylamines
  • Monocarboxylic acids and derivatives
  • N-acyl amines
  • N-acyl-alpha amino acids and derivatives
  • O-glycosyl compounds
  • Organochlorides
  • Oxacyclic compounds
  • Oxanes
  • Phenolic glycosides
  • Primary alcohols
  • Primary carboxylic acid amides
  • Resorcinols
  • Secondary alcohols
  • Secondary carboxylic acid amides

substituent:
  • 1,2-aminoalcohol
  • 1,2-diol
  • Acetal
  • Alcohol
  • Alpha-amino acid amide
  • Alpha-amino acid or derivatives
  • Amine
  • Amino saccharide
  • Amino sugar
  • Aromatic heteropolycyclic compound
  • Aryl chloride
  • Aryl halide
  • Azacycle
  • Benzenoid
  • Carbonyl group
  • Carboxamide group
  • Carboxylic acid
  • Carboxylic acid amide
  • Cyclic alpha peptide
  • Diaryl ether
  • Disaccharide
  • Ether
  • Fatty acyl
  • Fatty amide
  • Glycosyl compound
  • Hydrocarbon derivative
  • Lactam
  • Monocarboxylic acid or derivatives
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-amine
  • N-substituted-alpha-amino acid
  • O-glycosyl compound
  • Organochloride
  • Organohalogen compound
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Organooxygen compound
  • Oxacycle
  • Oxane
  • Phenolic glycoside
  • Polyol
  • Primary alcohol
  • Primary aliphatic amine
  • Primary amine
  • Primary carboxylic acid amide
  • Resorcinol
  • Saccharide
  • Secondary alcohol
  • Secondary aliphatic amine
  • Secondary amine
  • Secondary carboxylic acid amide

References

Synthesis Reference: # Boger DL. Vancomycin, teicoplanin, and ramoplanin: synthetic and mechanistic studies. Med Res Rev. 2001 Sep;21(5):356-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11579438
General Reference: # Schäfer, Martina, Thomas R Schneider, and George M Sheldrick. 1996. Crystal structure of vancomycin. Structure 4, no. 12 (December 15): 1509-1515. "DOI:10.1016/S0969-2126(96)00156-6":http://dx.doi.org/10.1016/S0969-2126(96)00156-6. # Levine DP: Vancomycin: a history. Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S5-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16323120 # Small PM, Chambers HF: Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users. Antimicrob Agents Chemother. 1990 Jun;34(6):1227-31. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2393284 # Gonzalez C, Rubio M, Romero-Vivas J, Gonzalez M, Picazo JJ: Bacteremic pneumonia due to Staphylococcus aureus: A comparison of disease caused by methicillin-resistant and methicillin-susceptible organisms. Clin Infect Dis. 1999 Nov;29(5):1171-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10524959 # Sivagnanam S, Deleu D: Red man syndrome. Crit Care. 2003 Apr;7(2):119-20. Epub 2002 Dec 23. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12720556 # Cantu TG, Yamanaka-Yuen NA, Lietman PS: Serum vancomycin concentrations: reappraisal of their clinical value. Clin Infect Dis. 1994 Apr;18(4):533-43. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8038306
External Links:
ResourceLink
RxListhttp://www.rxlist.com/cgi/generic2/vancomycin.htm
Drugs.comhttp://www.drugs.com/vancomycin.html

ATC Codes:
  • Array
  • Array

AHFS Codes:
  • 08:12.28.16

MSDS: Download
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