Detail

Valproic Acid

Description

Name: Valproic Acid
Type: small molecule
Groups: Array
Indication: For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome.
Accession Number: DB00313 ( APRD00066, APRD00256, DB00510)
Description: Valproic acid, supplied as the sodium salt valproate semisodium or divalproex sodium, is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels. Typically supplied in the sodium salt form (CAS number: 76584-70-8). Valproic Acid is also a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers.
Structure:
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Depaconinjection100 mg/mLintravenous30-12-1996US
Depakenecapsule, liquid filled250 mg/1oral28-02-1978US
Depakenesolution250 mg/5mLoral28-02-1978US
Depakenecapsule250 mgoral31-12-1978Canada
Depakenesolution50 mgoral31-12-1978Canada
Depakene Cap 500mgcapsule (enteric-coated)500 mgoral31-12-198111-05-2007Canada
Depakotetablet, extended release500 mg/1oral07-06-2010US
Depakotetablet, extended release500 mg/1oral18-11-2003US
Depakotetablet, extended release250 mg/1oral10-02-2006US
Depakotetablet, delayed release125 mg/1oral10-03-1983US
Depakotetablet, delayed release250 mg/1oral10-03-1983US
Depakotetablet, delayed release500 mg/1oral10-03-1983US
Depakotecapsule125 mg/1oral07-06-2010US
Depakotetablet, delayed release250 mg/1oral18-12-2014US
Depakotetablet, delayed release250 mg/1oral14-11-2011US
Depakotetablet, delayed release500 mg/1oral14-07-2014US
Depakotetablet, extended release250 mg/1oral07-06-2010US
Depakotetablet, extended release500 mg/1oral07-06-2010US
Depakote ERtablet, extended release250 mg/1oral04-08-2000US
Depakote ERtablet, extended release500 mg/1oral04-08-2000US
Depakote ERtablet, extended release500 mg/1oral04-08-2000US
Depakote ERtablet, extended release500 mg/1oral07-06-2010US
Depakote Sprinklescapsule125 mg/1oral12-09-1989US
Deproic Syrupsyrup250 mgoral02-06-199828-07-2006Canada
Divalproextablet (enteric-coated)125 mgoral13-02-2013Canada
Divalproextablet (enteric-coated)250 mgoral13-02-2013Canada
Divalproextablet (enteric-coated)500 mgoral13-02-2013Canada
Divalproex Sodium Delayed Release (sprinkle)capsule125 mg/1oral31-08-2015US
Divalproex Sodium Extended Releasetablet, extended release250 mg/1oral04-08-2000US
Divalproex Sodium Extended Releasetablet, extended release500 mg/1oral12-08-2013US
Divalproex Sodium Extended-releasetablet, extended release250 mg/1oral04-08-2000US
Divalproex Sodium Extended-releasetablet, extended release500 mg/1oral12-08-2013US
Divalproex Sodium Extended-releasetablet, extended release500 mg/1oral01-11-2014US
Divalproex-125tablet (enteric-coated)125 mgoral22-08-2001Canada
Divalproex-250tablet (enteric-coated)250 mgoral22-08-2001Canada
Divalproex-500tablet (enteric-coated)500 mgoral22-08-2001Canada
Dom-divalproextablet (enteric-coated)125 mgoral15-04-2002Canada
Dom-divalproextablet (enteric-coated)250 mgoral15-04-2002Canada
Dom-divalproextablet (enteric-coated)500 mgoral15-04-2002Canada
Dom-valproic Acidcapsule250 mgoral25-04-1998Canada
Dom-valproic Acid E.C.capsule (enteric-coated)500 mgoral22-10-1998Canada
Dom-valproic Acid Syrupsyrup250 mgoral08-03-1999Canada
Epiject I.V.liquid500 mgintravenous01-09-200005-10-2007Canada
Epivaltablet (enteric-coated)125 mgoral31-12-1984Canada
Epivaltablet (enteric-coated)250 mgoral31-12-1984Canada
Epivaltablet (enteric-coated)500 mgoral31-12-1984Canada
Epival ERtablet (extended-release)500 mgoral13-11-200006-06-2008Canada
Ftp-valproic Acidcapsule250 mgoral09-10-199803-08-2004Canada
Mylan-divalproextablet (delayed-release)125 mgoral04-03-2005Canada
Mylan-divalproextablet (delayed-release)250 mgoral04-03-2005Canada
Mylan-divalproextablet (delayed-release)500 mgoral04-03-2005Canada
Mylan-valproiccapsule250 mgoral31-12-1995Canada
Novo-valproiccapsule250 mgoral31-12-1995Canada
Novo-valproiccapsule (enteric-coated)500 mgoral07-01-1997Canada
Nu-divalproex 125mgtablet (enteric-coated)125 mgoral20-01-199904-09-2012Canada
Nu-divalproex 250mgtablet (enteric-coated)250 mgoral20-01-199904-09-2012Canada
Nu-divalproex 500mgtablet (enteric-coated)500 mgoral20-01-199904-09-2012Canada
Nu-valproiccapsule250 mgoral29-07-199804-09-2012Canada
Nu-valproic Syrupsyrup50 mgoral01-01-1970Canada
Penta-valproic Capsulescapsule250 mgoral01-01-1970Canada
PHL-divalproextablet (enteric-coated)125 mgoral01-08-2007Canada
PHL-divalproextablet (enteric-coated)250 mgoral25-10-2007Canada
PHL-divalproextablet (enteric-coated)500 mgoral25-10-2007Canada
PHL-valproic Acidcapsule250 mgoral02-12-2004Canada
PHL-valproic Acidsyrup250 mgoral03-09-1998Canada
PHL-valproic Acid E.C.capsule (enteric-coated)500 mgoral06-12-2004Canada
PMS-divalproex (125mg)tablet (enteric-coated)125 mgoral03-08-2001Canada
PMS-divalproex (250mg)tablet (enteric-coated)250 mgoral03-08-2001Canada
PMS-divalproex (500mg)tablet (enteric-coated)500 mgoral03-08-2001Canada
PMS-valproic Acidcapsule250 mgoral27-02-1997Canada
PMS-valproic Acidsyrup250 mgoral20-11-1997Canada
PMS-valproic Acid E.C.capsule (enteric-coated)500 mgoral13-12-1996Canada
Ratio-valproiccapsule250 mgoral04-11-1996Canada
Ratio-valproiccapsule (enteric-coated)500 mgoral28-08-1997Canada
Ratio-valproic - Ecc 500mgcapsule (enteric-coated)500 mgoral17-07-199602-08-2010Canada
Ratio-valproic 50mg/ml Syrupsyrup50 mgoral19-01-199826-10-2015Canada
Ratio-valproic-cap 250mgcapsule250 mgoral31-12-199519-09-2014Canada
Sandoz Valproiccapsule250 mgoral28-01-2000Canada
Sandoz Valproiccapsule (enteric-coated)500 mgoral28-01-200007-08-2008Canada
Teva-divalproextablet (enteric-coated)125 mgoral14-04-1999Canada
Teva-divalproextablet (enteric-coated)250 mgoral14-04-1999Canada
Teva-divalproextablet (enteric-coated)500 mgoral14-04-1999Canada
Valproic-250capsule250 mgoral25-11-199823-07-2012Canada

Generic Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Apo-divalproextablet (enteric-coated)125 mgoral24-03-1999Canada
Apo-divalproextablet (enteric-coated)250 mgoral24-03-1999Canada
Apo-divalproextablet (enteric-coated)500 mgoral24-03-1999Canada
Apo-valproiccapsule250 mgoral01-06-1998Canada
Apo-valproic Syrupsyrup50 mgoral15-07-1998Canada
Divalproex Sodiumtablet, delayed release125 mg/1oral21-01-2011US
Divalproex Sodiumtablet, delayed release250 mg/1oral21-01-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral21-01-2011US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral01-01-2013US
Divalproex Sodiumtablet, delayed release125 mg/1oral04-03-2015US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-07-2009US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-07-2009US
Divalproex Sodiumtablet, delayed release500 mg/1oral01-07-2009US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-09-2009US
Divalproex Sodiumtablet, delayed release500 mg/1oral15-06-2009US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral08-10-2013US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral08-10-2013US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release250 mg/1oral12-07-2011US
Divalproex Sodiumtablet, extended release250 mg/1oral20-07-2011US
Divalproex Sodiumtablet, extended release500 mg/1oral20-07-2011US
Divalproex Sodiumtablet, delayed release125 mg/1oral31-07-2008US
Divalproex Sodiumtablet, delayed release250 mg/1oral31-07-2008US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral02-06-2014US
Divalproex Sodiumtablet, extended release250 mg/1oral30-11-2010US
Divalproex Sodiumtablet, delayed release500 mg/1oral31-07-2008US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral02-06-2014US
Divalproex Sodiumtablet, extended release250 mg/1oral21-07-2011US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral29-01-2009US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral02-02-2009US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral03-02-2009US
Divalproex Sodiumtablet, delayed release125 mg/1oral21-01-2011US
Divalproex Sodiumtablet, delayed release250 mg/1oral21-01-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral21-01-2011US
Divalproex Sodiumtablet, delayed release250 mg/1oral05-11-2014US
Divalproex Sodiumtablet, delayed release125 mg/1oral24-10-2014US
Divalproex Sodiumtablet, delayed release500 mg/1oral12-07-2011US
Divalproex Sodiumtablet, delayed release125 mg/1oral03-06-2010US
Divalproex Sodiumtablet, delayed release250 mg/1oral03-06-2010US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral03-06-2010US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral01-07-2013US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral18-08-2010US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral01-07-2013US
Divalproex Sodiumcapsule, coated pellets125 mg/1oral27-01-2009US
Divalproex Sodiumtablet, extended release250 mg/1oral01-06-2015US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, extended release500 mg/1oral01-06-2015US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral28-08-2014US
Divalproex Sodiumtablet, delayed release500 mg/1oral04-04-2011US
Divalproex Sodiumtablet, delayed release125 mg/1oral29-07-2008US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral08-02-2010US
Divalproex Sodiumtablet, delayed release125 mg/1oral21-03-2014US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral08-02-2010US
Divalproex Sodiumtablet, delayed release250 mg/1oral21-03-2014US
Divalproex Sodiumtablet, delayed release500 mg/1oral21-03-2014US
Divalproex Sodiumcapsule125 mg/1oral23-01-2009US
Divalproex Sodiumtablet, delayed release500 mg/1oral01-10-2011US
Divalproex Sodiumtablet, delayed release125 mg/1oral06-03-2010US
Divalproex Sodiumtablet, delayed release250 mg/1oral06-03-2010US
Divalproex Sodiumtablet, delayed release125 mg/1oral21-04-201131-07-2016US
Divalproex Sodiumtablet, delayed release500 mg/1oral06-03-2010US
Divalproex Sodiumtablet, delayed release250 mg/1oral21-04-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral21-04-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral25-02-2011US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral20-10-2014US
Divalproex Sodiumtablet, extended release250 mg/1oral11-08-2013US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-01-2014US
Divalproex Sodiumtablet, extended release500 mg/1oral11-08-2013US
Divalproex Sodiumtablet, delayed release125 mg/1oral30-11-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral30-10-2014US
Divalproex Sodiumcapsule125 mg/1oral24-07-2012US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral03-02-2009US
Divalproex Sodiumtablet, delayed release125 mg/1oral06-04-2009US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral03-02-2009US
Divalproex Sodiumtablet, delayed release250 mg/1oral06-04-2009US
Divalproex Sodiumtablet, delayed release500 mg/1oral06-04-2009US
Divalproex Sodiumtablet, delayed release125 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumcapsule, coated pellets125 mg/1oral27-01-2009US
Divalproex Sodiumtablet, delayed release500 mg/1oral01-01-2014US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral20-08-2009US
Divalproex Sodiumtablet, delayed release250 mg/1oral21-04-2011US
Divalproex Sodiumtablet, delayed release250 mg/1oral26-11-2014US
Divalproex Sodiumtablet, delayed release500 mg/1oral21-04-2011US
Divalproex Sodiumtablet, delayed release125 mg/1oral24-10-2014US
Divalproex Sodiumtablet, delayed release125 mg/1oral03-01-2011US
Divalproex Sodiumcapsule, coated pellets125 mg/1oral01-04-2009US
Divalproex Sodiumtablet, delayed release250 mg/1oral17-10-2011US
Divalproex Sodiumtablet, delayed release250 mg/1oral07-10-2014US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-08-2011US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral23-02-2012US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral14-10-2011US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-10-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral07-10-2014US
Divalproex Sodiumcapsule125 mg/1oral14-12-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral01-10-2011US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral07-01-2013US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral07-01-2013US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral20-08-2009US
Divalproex Sodiumtablet, delayed release125 mg/1oral18-03-2011US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-01-2015US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral21-11-2013US
Divalproex Sodiumcapsule, coated pellets125 mg/1oral01-04-2009US
Divalproex Sodiumtablet, delayed release500 mg/1oral01-10-2011US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral28-02-2013US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral02-02-2009US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-11-2014US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral04-08-2009US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral04-08-2009US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral20-08-2009US
Divalproex Sodiumtablet, delayed release125 mg/1oral29-07-2008US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral04-08-2009US
Divalproex Sodiumtablet, delayed release125 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumcapsule125 mg/1oral23-01-2009US
Divalproex Sodiumtablet, extended release250 mg/1oral11-08-2013US
Divalproex Sodiumtablet, extended release500 mg/1oral11-08-2013US
Divalproex Sodiumtablet, delayed release125 mg/1oral09-03-2015US
Divalproex Sodiumtablet, delayed release500 mg/1oral15-10-2009US
Divalproex Sodiumtablet, delayed release125 mg/1oral08-06-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral01-01-2015US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-11-2014US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral20-11-2009US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral02-06-2014US
Divalproex Sodiumtablet, delayed release125 mg/1oral31-07-2008US
Divalproex Sodiumtablet, delayed release250 mg/1oral31-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral31-07-2008US
Divalproex Sodiumtablet, delayed release125 mg/1oral29-07-2008US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral21-11-2013US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral01-11-2014US
Divalproex Sodiumtablet, delayed release125 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumcapsule, delayed release125 mg/1oral28-03-2011US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral23-01-2012US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral23-01-2012US
Divalproex Sodiumtablet, delayed release250 mg/1oral29-07-2008US
Divalproex Sodiumtablet, delayed release500 mg/1oral29-07-2008US
Divalproex Sodiumtablet, film coated, extended release250 mg/1oral02-06-2014US
Divalproex Sodiumtablet, film coated, extended release500 mg/1oral02-06-2014US
Divalproex Sodiumtablet, delayed release125 mg/1oral01-10-2011US
Divalproex Sodiumtablet, delayed release250 mg/1oral01-10-2011US
Divalproex Sodiumtablet, delayed release500 mg/1oral01-10-2011US
Divalproex Sodiumtablet, delayed release125 mg/1oral06-03-2010US
Divalproex Sodiumtablet, delayed release250 mg/1oral06-03-2010US
Divalproex Sodiumtablet, delayed release500 mg/1oral06-03-2010US
Divalproex Sodium Delayed Releasetablet, delayed release500 mg/1oral16-11-2010US
Divalproex Sodium Delayed Releasetablet, delayed release500 mg/1oral20-04-2011US
Divalproex Sodium Delayed Releasetablet, delayed release250 mg/1oral20-04-2011US
Divalproex Sodium Delayed-releasetablet, delayed release500 mg/1oral01-06-2011US
Divalproex Sodium Delayed-releasetablet, film coated125 mg/1oral30-11-2009US
Divalproex Sodium Delayed-releasetablet, film coated250 mg/1oral30-11-2009US
Divalproex Sodium Delayed-releasetablet, film coated500 mg/1oral30-11-2009US
Divalproex Sodium Delayed-releasetablet, film coated250 mg/1oral30-11-2009US
Divalproex Sodium Delayed-releasetablet, film coated500 mg/1oral01-01-2013US
Divalproex Sodium Drtablet, delayed release125 mg/1oral14-10-2009US
Divalproex Sodium Drtablet, delayed release250 mg/1oral14-10-2009US
Divalproex Sodium Drtablet, delayed release500 mg/1oral14-10-2009US
Divalproex Sodium Drtablet, delayed release500 mg/1oral14-10-2009US
Divalproex Sodium Drtablet, delayed release500 mg/1oral14-10-2009US
Divalproex Sodium Drtablet, delayed release250 mg/1oral14-10-2009US
Divalproex Sodium Drtablet, delayed release250 mg/1oral14-10-200931-05-2016US
Divalproex Sodium Drtablet, delayed release500 mg/1oral14-10-200931-05-2016US
Divalproex Sodium Drtablet, delayed release particles500 mg/1oral29-07-2008US
Divalproex Sodium ERtablet, film coated, extended release250 mg/1oral10-02-2009US
Divalproex Sodium ERtablet, film coated, extended release500 mg/1oral04-08-2009US
Divalproex Sodium ERtablet, film coated, extended release250 mg/1oral10-02-2009US
Divalproex Sodium ERtablet, film coated, extended release500 mg/1oral04-08-2009US
Divalproex Sodium ERtablet, film coated, extended release500 mg/1oral04-08-2009US
Divalproex Sodium Extended Releasetablet, extended release500 mg/1oral24-11-2010US
Divalproex Sodium Extended Releasetablet, extended release500 mg/1oral06-05-2011US
Divalproex Sodium Extended-releasetablet, extended release250 mg/1oral14-10-200929-12-2015US
Divalproex Sodium Extended-releasetablet, extended release500 mg/1oral14-10-200929-12-2015US
Divalproex Sodium Extended-releasetablet, extended release500 mg/1oral04-08-2009US
Divalproex Sodium Extended-releasetablet, extended release500 mg/1oral14-10-2009US
Divalproex Sodium Extended-releasetablet, extended release250 mg/1oral26-02-2009US
Divalproex Sodium Extended-releasetablet, extended release500 mg/1oral04-08-2009US
Divalproex Sodiumdelayed-release Delayed-releasetablet, film coated500 mg/1oral30-11-2009US
Divalproex Sodiumdelayed-release Delayed-releasetablet, film coated250 mg/1oral25-02-2013US
Valproate Sodiuminjection100 mg/mLintravenous15-04-2013US
Valproate Sodiuminjection500 mg/5mLintravenous17-02-2010US
Valproate Sodiuminjection, solution100 mg/mLintravenous18-08-2003US
Valproiccapsule, liquid filled250 mg/1oral08-09-2009US
Valproiccapsule, liquid filled250 mg/1oral19-04-1994US
Valproiccapsule, liquid filled250 mg/1oral08-09-2009US
Valproiccapsule, liquid filled250 mg/1oral05-04-2010US
Valproiccapsule, liquid filled250 mg/1oral05-04-2010US
Valproiccapsule, liquid filled250 mg/1oral08-09-2009US
Valproic Acidcapsule250 mg/1oral29-10-2011US
Valproic Acidsolution250 mg/5mLoral13-01-1995US
Valproic Acidcapsule, liquid filled250 mg/1oral31-10-1993US
Valproic Acidsolution250 mg/5mLoral18-04-2012US
Valproic Acidcapsule250 mg/1oral29-10-1991US
Valproic Acidsolution250 mg/5mLoral13-01-1995US
Valproic Acidsolution250 mg/5mLoral13-10-2006US
Valproic Acidcapsule250 mg/1oral10-08-201229-12-2015US
Valproic Acidcapsule250 mg/1oral29-10-1991US
Valproic Acidcapsule, liquid filled250 mg/1oral01-06-2015US
Valproic Acidcapsule, liquid filled250 mg/1oral02-07-2015US
Valproic Acidcapsule250 mg/1oral29-10-1991US
Valproic Acidcapsule, liquid filled250 mg/1oral04-06-2010US
Valproic Acidsolution250 mg/5mLoral10-12-2003US
Valproic Acidsolution250 mg/5mLoral05-04-1995US
Valproic Acidsolution500 mg/10mLoral30-01-2007US
Valproic Acidsolution250 mg/5mLoral10-12-2003US
Valproic Acidcapsule, liquid filled250 mg/1oral01-03-2005US
Valproic Acidsolution250 mg/5mLoral13-01-1995US
Valproic Acidcapsule250 mg/1oral28-02-2013US
Valproic Acidtablet250 mg/1oral16-06-2011US
Valproic Acidsolution250 mg/5mLoral11-04-2005US
Valproic Acidsolution250 mg/5mLoral11-04-2005US
Valproic Acidcapsule, liquid filled250 mg/1oral29-06-1993US
Valproic Acidcapsule250 mg/1oral10-08-2012US
Valproic Acidcapsule, liquid filled250 mg/1oral30-12-2015US
Valproic Acidsolution250 mg/5mLoral11-04-2005US

Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
DepaconValproic Acid
Depakote ERValproic Acid
DepakeneValproic Acid
DepakeneValproic Acid
Depakote SprinklesValproic Acid
DepakoteValproic Acid
DepakoteValproic Acid
DepakoteValproic Acid
Depakote ERValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Valproic AcidValproic Acid
Valproate SodiumValproic Acid
Valproate SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
ValproicValproic Acid
Valproic AcidValproic Acid
Divalproex Sodium Delayed-releaseValproic Acid
Divalproex Sodium Delayed-releaseValproic Acid
Divalproex Sodium Delayed-releaseValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
ValproicValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Delayed Release (sprinkle)Valproic Acid
Valproic AcidValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex Sodium DrValproic Acid
Valproic AcidValproic Acid
DepakoteValproic Acid
DepakoteValproic Acid
Valproic AcidValproic Acid
Divalproex Sodium DrValproic Acid
Divalproex Sodium DrValproic Acid
Divalproex Sodium DrValproic Acid
Divalproex Sodium Delayed-releaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodiumdelayed-release Delayed-releaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium DrValproic Acid
Divalproex SodiumValproic Acid
Depakote ERValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Delayed ReleaseValproic Acid
Divalproex Sodium Extended ReleaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Delayed ReleaseValproic Acid
Divalproex Sodium Delayed ReleaseValproic Acid
Divalproex Sodium Extended ReleaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
DepakoteValproic Acid
Valproic AcidValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodiumdelayed-release Delayed-releaseValproic Acid
DepakoteValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Delayed-releaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
ValproicValproic Acid
DepakoteValproic Acid
DepakoteValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
DepakoteValproic Acid
Valproic AcidValproic Acid
DepakoteValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex Sodium DrValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex Sodium DrValproic Acid
Valproic AcidValproic Acid
Divalproex Sodium ERValproic Acid
Divalproex Sodium ERValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
ValproicValproic Acid
Valproic AcidValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
DepakoteValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Valproate SodiumValproic Acid
Depakote ERValproic Acid
Divalproex Sodium Delayed-releaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium ERValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium ERValproic Acid
Divalproex Sodium ERValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
ValproicValproic Acid
ValproicValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium DrValproic Acid
Divalproex Sodium DrValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex Sodium Extended ReleaseValproic Acid
Divalproex Sodium Extended ReleaseValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Valproic AcidValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex Sodium Extended-releaseValproic Acid
Divalproex SodiumValproic Acid
Divalproex SodiumValproic Acid
Novo-valproicValproic Acid
Mylan-valproicValproic Acid
Ratio-valproicValproic Acid
Novo-valproicValproic Acid
PMS-valproic Acid E.C.Valproic Acid
PMS-valproic AcidValproic Acid
Dom-valproic AcidValproic Acid
Dom-valproic Acid E.C.Valproic Acid
Ratio-valproicValproic Acid
EpivalValproic Acid
EpivalValproic Acid
EpivalValproic Acid
PMS-valproic AcidValproic Acid
Apo-valproicValproic Acid
PHL-valproic AcidValproic Acid
Apo-valproic SyrupValproic Acid
Dom-valproic Acid SyrupValproic Acid
Apo-divalproexValproic Acid
Apo-divalproexValproic Acid
Apo-divalproexValproic Acid
Sandoz ValproicValproic Acid
Divalproex-125Valproic Acid
Divalproex-250Valproic Acid
Divalproex-500Valproic Acid
PMS-divalproex (125mg)Valproic Acid
PMS-divalproex (250mg)Valproic Acid
PMS-divalproex (500mg)Valproic Acid
Dom-divalproexValproic Acid
Dom-divalproexValproic Acid
Dom-divalproexValproic Acid
PHL-valproic AcidValproic Acid
PHL-valproic Acid E.C.Valproic Acid
Mylan-divalproexValproic Acid
Mylan-divalproexValproic Acid
Mylan-divalproexValproic Acid
PHL-divalproexValproic Acid
PHL-divalproexValproic Acid
PHL-divalproexValproic Acid
DivalproexValproic Acid
DivalproexValproic Acid
DivalproexValproic Acid
Ratio-valproic-cap 250mgValproic Acid
Ratio-valproic - Ecc 500mgValproic Acid
Depakene Cap 500mgValproic Acid
Nu-valproicValproic Acid
Deproic SyrupValproic Acid
Epiject I.V.Valproic Acid
Ftp-valproic AcidValproic Acid
Valproic-250Valproic Acid
Nu-divalproex 125mgValproic Acid
Nu-divalproex 250mgValproic Acid
Nu-divalproex 500mgValproic Acid
Sandoz ValproicValproic Acid
Epival ERValproic Acid
Penta-valproic CapsulesValproic Acid
Nu-valproic SyrupValproic Acid
DepakeneValproic Acid
DepakeneValproic Acid
Teva-divalproexValproic Acid
Teva-divalproexValproic Acid
Teva-divalproexValproic Acid
Ratio-valproic 50mg/ml SyrupValproic Acid

Categories
  • Enzyme Inhibitors
  • Anticonvulsants
  • Antimanic Agents
  • GABA Agents
  • Valproate Products

Pharmacology

Indication: For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome.
Pharmacodynamics: Not Available
Mechanism of action: Valproic Acid dissociates to the valproate ion in the gastrointestinal tract and then binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Valproic Acid may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. It is also a histone deacetylase inhibitor. Valproic acid has also been shown to be an inhibitor of an enzyme called histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV to remain in infected cells. A study published in August 2005 revealed that patients treated with valproic acid in addition to highly active antiretroviral therapy (HAART) showed a 75% reduction in latent HIV infection.
Absorption: Rapid absorption from gastrointestinal tract. Although the rate of valproate ion absorption may vary with the formulation administered (liquid, solid, or sprinkle), conditions of use (e.g., fasting or postprandial) and the method of administration (e.g., whether the contents of the capsule are sprinkled on food or the capsule is taken intact), these differences should be of minor clinical importance under the steady state conditions achieved in chronic use in the treatment of epilepsy. Food has a greater influence on the rate of absorption of the Depakote tablet (increases Tmax from 4 to 8 hours) than on the absorption of Depakote sprinkle capsules (increase Tmax from 3.3 to 4.8 hours). Furthermore, studies suggest that total daily systemic bioavailability (extent of absorption) is the primary determinant of seizure control.
Volume of distribution:
  • 11 L/1.73 m2 [total valproate]
  • 92 L/1.73 m2 [free valproate]

Protein binding: Concentration-dependent, from 90% at 40 µg/mL to 81.5% at 130 µg/mL. Higher than expected free fractions occur in the elderly, in hyperlipidemic patients, and in patients with hepatic and renal diseases. It may also affect the extent of protein binding of other drugs such as phenytoin or carbamazepine.
Metabolism: Not Available
Route of elimination: Valproate is metabolized almost entirely by the liver. Less than 3% of an administered dose is excreted unchanged in urine. Mitochondrial ß-oxidation is the other major metabolic pathway, typically accounting for over 40% of the dose.
Half life: 9-16 hours (following oral administration of 250 mg to 1000 mg)
Clearance: Not Available
Toxicity: Oral, mouse: LD50 = 1098 mg/kg; Oral, rat: LD50 = 670 mg/kg. Symptoms of overdose may include coma, extreme drowsiness, and heart problems. The safety and tolerability of valproate in pediatric patients were shown to be comparable to those in adults.
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Banner pharmacaps inc
  • Abbott laboratories pharmaceutical products div
  • Catalent pharma solutions llc
  • Par pharmaceutical inc
  • Rp scherer north america div rp scherer corp
  • Usl pharma inc
  • Alpharma uspd inc
  • Apotex inc richmond hill
  • High technology pharmacal co inc
  • Pharmaceutical assoc inc div beach products
  • Sun pharmaceutical industries inc
  • Teva pharmaceuticals usa
  • Vintage pharmaceuticals llc
  • Wockhardt eu operations (swiss) ag

Packagers:
Dosage forms
FormRouteStrength
Syruporal50 mg
Injectionintravenous100 mg/mL
Capsule, liquid filledoral250 mg/1
Solutionoral250 mg/5mL
Solutionoral50 mg
Tablet, delayed releaseoral125 mg/1
Tablet, delayed releaseoral250 mg/1
Tablet, delayed releaseoral500 mg/1
Tablet, extended releaseoral250 mg/1
Tablet, extended releaseoral500 mg/1
Capsuleoral125 mg/1
Capsule, coated pelletsoral125 mg/1
Capsule, delayed releaseoral125 mg/1
Tablet, film coated, extended releaseoral250 mg/1
Tablet, film coated, extended releaseoral500 mg/1
Tablet, film coatedoral125 mg/1
Tablet, film coatedoral250 mg/1
Tablet, film coatedoral500 mg/1
Tablet, delayed release particlesoral500 mg/1
Liquidintravenous500 mg
Tablet (enteric-coated)oral125 mg
Tablet (enteric-coated)oral250 mg
Tablet (enteric-coated)oral500 mg
Tablet (extended-release)oral500 mg
Tablet (delayed-release)oral125 mg
Tablet (delayed-release)oral250 mg
Tablet (delayed-release)oral500 mg
Capsuleoral250 mg
Capsule (enteric-coated)oral500 mg
Syruporal250 mg
Injectionintravenous500 mg/5mL
Injection, solutionintravenous100 mg/mL
Capsuleoral250 mg/1
Solutionoral500 mg/10mL
Tabletoral250 mg/1

Prices
Unit descriptionCostUnit
Depakene 250 mg capsule$2.21capsule
Valproic acid liquid$10.2g
Apo-Valproic 50 mg/ml Syrup$0.06ml
Pms-Valproic Acid 50 mg/ml Syrup$0.06ml
Ratio-Valproic 50 mg/ml Syrup$0.06ml
Depakene 50 mg/ml Syrup$0.11ml
Valproic acid 250 mg/5 ml syr$0.15ml
Valproic Acid 250 mg/5ml Syrup$0.16ml
Apo-Valproic 250 mg Capsule$0.27capsule
Mylan-Valproic 250 mg Capsule$0.27capsule
Novo-Valproic 250 mg Capsule$0.27capsule
Nu-Valproic 250 mg Capsule$0.27capsule
Pms-Valproic Acid 250 mg Capsule$0.27capsule
Ratio-Valproic 250 mg Capsule$0.27capsule
Sandoz Valproic 250 mg Capsule$0.27capsule
Novo-Valproic 500 mg Enteric-Coated Capsule$0.54capsule
Pms-Valproic Acid E.C. 500 mg Enteric-Coated Capsule$0.54capsule
Depakene 250 mg/5ml Syrup$0.66ml
Valproic acid 250 mg capsule$0.79capsule

Patents
CountryPatent NumberApprovedExpires (estimated)
6511678United States1999-06-182019-06-18

Interactions

Drug Interactions
DrugInteraction
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Valproic Acid.
Acetylsalicylic acidThe serum concentration of Valproic Acid can be increased when it is combined with Acetylsalicylic acid.
Aminosalicylic AcidThe serum concentration of Valproic Acid can be increased when it is combined with Aminosalicylic Acid.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Valproic Acid.
AmobarbitalThe serum concentration of Amobarbital can be increased when it is combined with Valproic Acid.
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Valproic Acid.
AtazanavirThe serum concentration of Valproic Acid can be decreased when it is combined with Atazanavir.
BatimastatThe serum concentration of Valproic Acid can be decreased when it is combined with Batimastat.
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Valproic Acid.
Bismuth SubsalicylateThe serum concentration of Valproic Acid can be increased when it is combined with Bismuth Subsalicylate.
ButabarbitalThe serum concentration of Butabarbital can be increased when it is combined with Valproic Acid.
ButalbitalThe serum concentration of Butalbital can be increased when it is combined with Valproic Acid.
ButethalThe serum concentration of Butethal can be increased when it is combined with Valproic Acid.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Valproic Acid.
CarbamazepineThe serum concentration of the active metabolites of Carbamazepine can be increased when Carbamazepine is used in combination with Valproic Acid.
ChlorpromazineThe serum concentration of Valproic Acid can be increased when it is combined with Chlorpromazine.
CilastatinThe serum concentration of Valproic Acid can be decreased when it is combined with Cilastatin.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Valproic Acid.
CosyntropinCosyntropin may increase the hepatotoxic activities of Valproic Acid.
DarunavirThe serum concentration of Valproic Acid can be decreased when it is combined with Darunavir.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Valproic Acid.
DihydrocodeineThe serum concentration of Valproic Acid can be increased when it is combined with Dihydrocodeine.
DoripenemThe serum concentration of Valproic Acid can be decreased when it is combined with doripenem.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Valproic Acid.
ErtapenemThe serum concentration of Valproic Acid can be decreased when it is combined with Ertapenem.
EthosuximideThe serum concentration of Valproic Acid can be decreased when it is combined with Ethosuximide.
FelbamateThe serum concentration of Valproic Acid can be increased when it is combined with Felbamate.
FosamprenavirThe serum concentration of Valproic Acid can be decreased when it is combined with Fosamprenavir.
FosphenytoinThe serum concentration of Fosphenytoin can be decreased when it is combined with Valproic Acid.
Gamma Hydroxybutyric AcidThe serum concentration of Gamma Hydroxybutyric Acid can be increased when it is combined with Valproic Acid.
Glycerol PhenylbutyrateThe therapeutic efficacy of Glycerol Phenylbutyrate can be decreased when used in combination with Valproic Acid.
GuanfacineThe serum concentration of Valproic Acid can be increased when it is combined with Guanfacine.
HeptabarbitalThe serum concentration of Heptabarbital can be increased when it is combined with Valproic Acid.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Valproic Acid.
ImipenemThe serum concentration of Valproic Acid can be decreased when it is combined with Imipenem.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Valproic Acid.
IndinavirThe serum concentration of Valproic Acid can be decreased when it is combined with Indinavir.
IsoflurophateThe serum concentration of Valproic Acid can be decreased when it is combined with Isoflurophate.
LamotrigineThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Lamotrigine.
LopinavirThe serum concentration of Valproic Acid can be decreased when it is combined with Lopinavir.
LorazepamThe serum concentration of Lorazepam can be increased when it is combined with Valproic Acid.
Magnesium salicylateThe serum concentration of Valproic Acid can be increased when it is combined with Magnesium salicylate.
MefloquineThe therapeutic efficacy of Valproic Acid can be decreased when used in combination with Mefloquine.
MeropenemThe serum concentration of Valproic Acid can be decreased when it is combined with Meropenem.
MethohexitalThe serum concentration of Methohexital can be increased when it is combined with Valproic Acid.
MianserinThe therapeutic efficacy of Valproic Acid can be decreased when used in combination with Mianserin.
MinoxidilThe serum concentration of Minoxidil can be increased when it is combined with Valproic Acid.
NelfinavirThe serum concentration of Valproic Acid can be decreased when it is combined with Nelfinavir.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Valproic Acid.
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Valproic Acid.
OrlistatThe serum concentration of Valproic Acid can be decreased when it is combined with Orlistat.
OxcarbazepineThe serum concentration of Oxcarbazepine can be decreased when it is combined with Valproic Acid.
PaliperidoneThe serum concentration of Paliperidone can be increased when it is combined with Valproic Acid.
PentobarbitalThe serum concentration of Pentobarbital can be increased when it is combined with Valproic Acid.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Valproic Acid.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Valproic Acid.
PrimidoneThe metabolism of Primidone can be decreased when combined with Valproic Acid.
PromazineThe serum concentration of Valproic Acid can be increased when it is combined with Promazine.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Valproic Acid.
RifampicinThe serum concentration of Valproic Acid can be decreased when it is combined with Rifampicin.
RisperidoneThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Risperidone.
RitonavirThe serum concentration of Valproic Acid can be decreased when it is combined with Ritonavir.
RufinamideThe serum concentration of Rufinamide can be increased when it is combined with Valproic Acid.
Salicylate-sodiumThe serum concentration of Valproic Acid can be increased when it is combined with Salicylate-sodium.
SalsalateThe serum concentration of Valproic Acid can be increased when it is combined with Salsalate.
SaquinavirThe serum concentration of Valproic Acid can be decreased when it is combined with Saquinavir.
SecobarbitalThe serum concentration of Secobarbital can be increased when it is combined with Valproic Acid.
SimeprevirThe serum concentration of Valproic Acid can be decreased when it is combined with Simeprevir.
Sodium oxybateThe serum concentration of Sodium oxybate can be increased when it is combined with Valproic Acid.
Sodium phenylbutyrateThe therapeutic efficacy of Sodium phenylbutyrate can be decreased when used in combination with Valproic Acid.
TemozolomideThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Temozolomide.
TipranavirThe serum concentration of Valproic Acid can be decreased when it is combined with Tipranavir.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Valproic Acid.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Valproic Acid.
VorinostatValproic Acid may increase the thrombocytopenic activities of Vorinostat.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Valproic Acid.

Food Interactions:
  • Avoid alcohol.
  • Do not take with milk.
  • Take with food.

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Carbonyl compounds
  • Carboxylic acids
  • Hydrocarbon derivatives
  • Monocarboxylic acids and derivatives

substituent:
  • Aliphatic acyclic compound
  • Carbonyl group
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Methyl-branched fatty acid
  • Monocarboxylic acid or derivatives
  • Organooxygen compound

References

Synthesis Reference: Daniel Aubert, Francis Blanc, Henri Desmolin, Michel Morre, Lucette Sindely, "Valproic acid preparations." U.S. Patent US5017613, issued January, 1965.
General Reference: # Rosenberg G: The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 2007 Aug;64(16):2090-103. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17514356 # Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM: Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet. 2005 Aug 13-19;366(9485):549-55. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16099290 # Schwartz C, Palissot V, Aouali N, Wack S, Brons NH, Leners B, Bosseler M, Berchem G: Valproic acid induces non-apoptotic cell death mechanisms in multiple myeloma cell lines. Int J Oncol. 2007 Mar;30(3):573-82. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17273758 # Valentini A, Gravina P, Federici G, Bernardini S: Valproic acid induces apoptosis, p16INK4A upregulation and sensitization to chemotherapy in human melanoma cells. Cancer Biol Ther. 2007 Feb;6(2):185-91. Epub 2007 Feb 5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17218782 # FDA label
External Links:
ResourceLink
RxListhttp://www.rxlist.com/cgi/generic2/depakene.htm
PDRhealthhttp://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dep1124.shtml
Drugs.comhttp://www.drugs.com/cdi/valproate.html

ATC Codes:
  • Array

AHFS Codes:
  • 28:12.92

MSDS: Download
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The Purple Society website is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through this site should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.

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