Detail

VEGF-AS

Description

Name: VEGF-AS
Type: small molecule
Groups: investigational
Indication: Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
Accession Number: DB05890 ( DB05890)
Description: VEGF-AS (Veglin) is an anti-angiogenesis non-chemotherapy drug (angiogenesis inhibitor) that was developed by VasGene Therapeutics, Inc. for the treatment of a variety of malignancies including mesothelioma. Veglin is one of several newly developed non-chemotherapy drugs being tested for possible utilization in the ongoing struggle to combat malignant mesothelioma.
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Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
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Pharmacology

Indication: Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
Pharmacodynamics: Not Available
Mechanism of action: (VEGF-AS)Veglin is an antisense oligonucleotide that binds with DNA genes that are responsible for the production of proteins called Vascular Endothelial Growth Factors (VEGF), with the intention of inhibiting their production. VEGF (Vascular Endothelial Growth Factor) is an essential family of naturally-occurring growth factors found in humans and other animals that stimulates growth and supports survival of cells of the vascular system. VEGF is necessary for production of the blood vessels that transport nutrients and oxygen to cells and organs (angiogenesis). Without these vessels, tumors have limited capacity to grow. In addition, certain tumor cells themselves express the receptors for VEGF, and use VEGF as a growth stimulus.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
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Taxonomy

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References

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MSDS: Download
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