R450
Description
Type: small molecule
Groups: investigational
Indication: Investigated for use/treatment in urinary incontinence.
Accession Number: DB05469 ( DB05469)
Description: R450 is an alpha 1 antagonist that acts to tighten the muscle tone in the bladder. It is being considered for treatment of stress-related urinary incontinence. Phase IIa data for the drug show it reduced the number of incontinent episodes compared to placebo with minimal cardiovascular effects.
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
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Pharmacology
Pharmacodynamics: Not Available
Mechanism of action: R450 is a selective alpha 1 adrenoreceptor antagonist. Research on the management of urinary incontinence suggests that it is most likely an antagonist at alpha-1B and alpha-1D, while it acts as an agonist on alpha-1a.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms
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SNP Mediated Adverse Drug Reactions
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Pharmacoeconomics
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Packagers:
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Patents
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Food Interactions:
- Not Available
Taxonomy
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
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substituent:
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References
General Reference: Not Available
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ATC Codes:
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AHFS Codes:
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MSDS: Download