Detail

Pargyline

Description

Name: Pargyline
Type: small molecule
Groups: approved
Indication: For the treatment of moderate to severe hypertension.
Accession Number: DB01626 ( DB01626)
Description: A monoamine oxidase inhibitor with antihypertensive properties. [PubChem]
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients

Categories
  • No Category

Pharmacology

Indication: For the treatment of moderate to severe hypertension.
Pharmacodynamics: Not Available
Mechanism of action: MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Pargyline functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Catecholamines cause general physiological changes that prepare the body for physical activity (fight-or-flight response). Some typical effects are increases in heart rate, blood pressure, blood glucose levels, and a general reaction of the sympathetic nervous system.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
  • Not Available

Dosage forms
FormRouteStrength

Prices
Unit descriptionCostUnit

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction

Food Interactions:
  • Food increases the oral bioavailability by 3-5 fold.

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Aralkylamines
  • Benzylamines
  • Hydrocarbon derivatives
  • Trialkylamines

substituent:
  • Amine
  • Aralkylamine
  • Aromatic homomonocyclic compound
  • Benzylamine
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Phenylmethylamine
  • Tertiary aliphatic amine
  • Tertiary amine

References

Synthesis Reference: Not Available
General Reference: Not Available
External Links:
ResourceLink

ATC Codes:
  • Array

AHFS Codes:
  • Not Available

MSDS: Download
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