Name: Parecoxib

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Type: small molecule

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Groups: approved

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Indication: Used for short term perioperative pain control.

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Accession Number: DB08439 ( DB08439)

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Description: Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. In 2005, the U.S. Food and Drug Administration (FDA) issued a letter of non-approval for parecoxib in the United States.

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Structure:

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Prescription Products: Not Available

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Generic Prescription Products: Not Available

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Over the Counter Products: Not Available

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International Brands

• No Brands

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Brand Names

• No Brands

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Brand Mixtures

Brand Name	Ingredients

Brand Name	Ingredients

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Categories

• No Category

Indication: Used for short term perioperative pain control.

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Pharmacodynamics: Not Available

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Mechanism of action: Not Available

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Absorption: Not Available

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Volume of distribution: Not Available

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Protein binding: 98%

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Metabolism: Not Available

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Route of elimination: Not Available

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Half life: 22 minutes (parecoxib); 8 hours (valdecoxib)

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Clearance: Not Available

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Toxicity: Not Available

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Affected organisms

• Not Available

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SNP Mediated Adverse Drug Reactions

• Not Available

Manufacturers:

• Not Available

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Packagers:

• Not Available

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Dosage forms

Form	Route	Strength

Form	Route	Strength

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Prices

Unit description	Cost	Unit

Unit description	Cost	Unit

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Patents

Country	Patent Number	Approved	Expires (estimated)

Drug Interactions

Drug	Interaction
Atazanavir	The serum concentration of Parecoxib can be increased when it is combined with Atazanavir.
Boceprevir	The serum concentration of Parecoxib can be increased when it is combined with Boceprevir.
Capecitabine	The serum concentration of Parecoxib can be increased when it is combined with Capecitabine.
Ceritinib	The serum concentration of Parecoxib can be increased when it is combined with Ceritinib.
Clarithromycin	The serum concentration of Parecoxib can be increased when it is combined with Clarithromycin.
Cobicistat	The serum concentration of Parecoxib can be increased when it is combined with Cobicistat.
Darunavir	The serum concentration of Parecoxib can be increased when it is combined with Darunavir.
Delavirdine	The serum concentration of Parecoxib can be increased when it is combined with Delavirdine.
Dextromethorphan	The serum concentration of Dextromethorphan can be increased when it is combined with Parecoxib.
Floxuridine	The serum concentration of Parecoxib can be increased when it is combined with Floxuridine.
Fluconazole	The serum concentration of Parecoxib can be increased when it is combined with Fluconazole.
Fluorouracil	The serum concentration of Parecoxib can be increased when it is combined with Fluorouracil.
Gemfibrozil	The serum concentration of Parecoxib can be increased when it is combined with Gemfibrozil.
Idelalisib	The serum concentration of Parecoxib can be increased when it is combined with Idelalisib.
Indinavir	The serum concentration of Parecoxib can be increased when it is combined with Indinavir.
Itraconazole	The serum concentration of Parecoxib can be increased when it is combined with Itraconazole.
Ketoconazole	The serum concentration of Parecoxib can be increased when it is combined with Ketoconazole.
Nefazodone	The serum concentration of Parecoxib can be increased when it is combined with Nefazodone.
Nelfinavir	The serum concentration of Parecoxib can be increased when it is combined with Nelfinavir.
Nicardipine	The serum concentration of Parecoxib can be increased when it is combined with Nicardipine.
Posaconazole	The serum concentration of Parecoxib can be increased when it is combined with Posaconazole.
Ritonavir	The serum concentration of Parecoxib can be increased when it is combined with Ritonavir.
Saquinavir	The serum concentration of Parecoxib can be increased when it is combined with Saquinavir.
Sulfadiazine	The serum concentration of Parecoxib can be increased when it is combined with Sulfadiazine.
Telaprevir	The serum concentration of Parecoxib can be increased when it is combined with Telaprevir.
Telithromycin	The serum concentration of Parecoxib can be increased when it is combined with Telithromycin.
Tolbutamide	The serum concentration of Parecoxib can be increased when it is combined with Tolbutamide.
Voriconazole	The serum concentration of Parecoxib can be increased when it is combined with Voriconazole.

Drug	Interaction
Atazanavir	The serum concentration of Parecoxib can be increased when it is combined with Atazanavir.
Boceprevir	The serum concentration of Parecoxib can be increased when it is combined with Boceprevir.
Capecitabine	The serum concentration of Parecoxib can be increased when it is combined with Capecitabine.
Ceritinib	The serum concentration of Parecoxib can be increased when it is combined with Ceritinib.
Clarithromycin	The serum concentration of Parecoxib can be increased when it is combined with Clarithromycin.
Cobicistat	The serum concentration of Parecoxib can be increased when it is combined with Cobicistat.
Darunavir	The serum concentration of Parecoxib can be increased when it is combined with Darunavir.
Delavirdine	The serum concentration of Parecoxib can be increased when it is combined with Delavirdine.
Dextromethorphan	The serum concentration of Dextromethorphan can be increased when it is combined with Parecoxib.
Floxuridine	The serum concentration of Parecoxib can be increased when it is combined with Floxuridine.
Fluconazole	The serum concentration of Parecoxib can be increased when it is combined with Fluconazole.
Fluorouracil	The serum concentration of Parecoxib can be increased when it is combined with Fluorouracil.
Gemfibrozil	The serum concentration of Parecoxib can be increased when it is combined with Gemfibrozil.
Idelalisib	The serum concentration of Parecoxib can be increased when it is combined with Idelalisib.
Indinavir	The serum concentration of Parecoxib can be increased when it is combined with Indinavir.
Itraconazole	The serum concentration of Parecoxib can be increased when it is combined with Itraconazole.
Ketoconazole	The serum concentration of Parecoxib can be increased when it is combined with Ketoconazole.
Nefazodone	The serum concentration of Parecoxib can be increased when it is combined with Nefazodone.
Nelfinavir	The serum concentration of Parecoxib can be increased when it is combined with Nelfinavir.
Nicardipine	The serum concentration of Parecoxib can be increased when it is combined with Nicardipine.
Posaconazole	The serum concentration of Parecoxib can be increased when it is combined with Posaconazole.
Ritonavir	The serum concentration of Parecoxib can be increased when it is combined with Ritonavir.
Saquinavir	The serum concentration of Parecoxib can be increased when it is combined with Saquinavir.
Sulfadiazine	The serum concentration of Parecoxib can be increased when it is combined with Sulfadiazine.
Telaprevir	The serum concentration of Parecoxib can be increased when it is combined with Telaprevir.
Telithromycin	The serum concentration of Parecoxib can be increased when it is combined with Telithromycin.
Tolbutamide	The serum concentration of Parecoxib can be increased when it is combined with Tolbutamide.
Voriconazole	The serum concentration of Parecoxib can be increased when it is combined with Voriconazole.

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Food Interactions:

• Not Available

Kingdom: Organic compounds

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Super Class: Not Available

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Class: Not Available

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Sub Class: Not Available

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Direct Parent: Not Available

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Alternative Parents:

• Aminosulfonyl compounds
• Azacyclic compounds
• Carbonyl compounds
• Carboxylic acid amides
• Heteroaromatic compounds
• Hydrocarbon derivatives
• Isoxazoles
• Organonitrogen compounds
• Oxacyclic compounds
• Oxazoles
• Sulfonamides

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substituent:

• Aminosulfonyl compound
• Aromatic heteromonocyclic compound
• Azacycle
• Azole
• Benzenesulfonamide
• Carbonyl group
• Carboxamide group
• Carboxylic acid derivative
• Heteroaromatic compound
• Hydrocarbon derivative
• Isoxazole
• Organoheterocyclic compound
• Organonitrogen compound
• Organooxygen compound
• Organosulfur compound
• Oxacycle
• Oxazole
• Sulfonamide
• Sulfonic acid derivative
• Sulfonyl

Synthesis Reference: Not Available

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General Reference: Not Available

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External Links:

Resource	Link

Resource	Link

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ATC Codes:

• Array

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AHFS Codes:

• Not Available

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MSDS: Download