Parecoxib
Description
Type: small molecule
Groups: approved
Indication: Used for short term perioperative pain control.
Accession Number: DB08439 ( DB08439)
Description: Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. In 2005, the U.S. Food and Drug Administration (FDA) issued a letter of non-approval for parecoxib in the United States.
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
- No Brands
Brand Names
- No Brands
Brand Mixtures
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Brand Name | Ingredients |
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Categories
- No Category
Pharmacology
Pharmacodynamics: Not Available
Mechanism of action: Not Available
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: 98%
Metabolism: Not Available
Route of elimination: Not Available
Half life: 22 minutes (parecoxib); 8 hours (valdecoxib)
Clearance: Not Available
Toxicity: Not Available
Affected organisms
- Not Available
SNP Mediated Adverse Drug Reactions
- Not Available
Pharmacoeconomics
- Not Available
Packagers:
- Not Available
Dosage forms
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Form | Route | Strength |
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Prices
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Unit description | Cost | Unit |
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Patents
Country | Patent Number | Approved | Expires (estimated) |
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Interactions
Drug | Interaction |
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Atazanavir | The serum concentration of Parecoxib can be increased when it is combined with Atazanavir. |
Boceprevir | The serum concentration of Parecoxib can be increased when it is combined with Boceprevir. |
Capecitabine | The serum concentration of Parecoxib can be increased when it is combined with Capecitabine. |
Ceritinib | The serum concentration of Parecoxib can be increased when it is combined with Ceritinib. |
Clarithromycin | The serum concentration of Parecoxib can be increased when it is combined with Clarithromycin. |
Cobicistat | The serum concentration of Parecoxib can be increased when it is combined with Cobicistat. |
Darunavir | The serum concentration of Parecoxib can be increased when it is combined with Darunavir. |
Delavirdine | The serum concentration of Parecoxib can be increased when it is combined with Delavirdine. |
Dextromethorphan | The serum concentration of Dextromethorphan can be increased when it is combined with Parecoxib. |
Floxuridine | The serum concentration of Parecoxib can be increased when it is combined with Floxuridine. |
Fluconazole | The serum concentration of Parecoxib can be increased when it is combined with Fluconazole. |
Fluorouracil | The serum concentration of Parecoxib can be increased when it is combined with Fluorouracil. |
Gemfibrozil | The serum concentration of Parecoxib can be increased when it is combined with Gemfibrozil. |
Idelalisib | The serum concentration of Parecoxib can be increased when it is combined with Idelalisib. |
Indinavir | The serum concentration of Parecoxib can be increased when it is combined with Indinavir. |
Itraconazole | The serum concentration of Parecoxib can be increased when it is combined with Itraconazole. |
Ketoconazole | The serum concentration of Parecoxib can be increased when it is combined with Ketoconazole. |
Nefazodone | The serum concentration of Parecoxib can be increased when it is combined with Nefazodone. |
Nelfinavir | The serum concentration of Parecoxib can be increased when it is combined with Nelfinavir. |
Nicardipine | The serum concentration of Parecoxib can be increased when it is combined with Nicardipine. |
Posaconazole | The serum concentration of Parecoxib can be increased when it is combined with Posaconazole. |
Ritonavir | The serum concentration of Parecoxib can be increased when it is combined with Ritonavir. |
Saquinavir | The serum concentration of Parecoxib can be increased when it is combined with Saquinavir. |
Sulfadiazine | The serum concentration of Parecoxib can be increased when it is combined with Sulfadiazine. |
Telaprevir | The serum concentration of Parecoxib can be increased when it is combined with Telaprevir. |
Telithromycin | The serum concentration of Parecoxib can be increased when it is combined with Telithromycin. |
Tolbutamide | The serum concentration of Parecoxib can be increased when it is combined with Tolbutamide. |
Voriconazole | The serum concentration of Parecoxib can be increased when it is combined with Voriconazole. |
Drug | Interaction |
---|---|
Atazanavir | The serum concentration of Parecoxib can be increased when it is combined with Atazanavir. |
Boceprevir | The serum concentration of Parecoxib can be increased when it is combined with Boceprevir. |
Capecitabine | The serum concentration of Parecoxib can be increased when it is combined with Capecitabine. |
Ceritinib | The serum concentration of Parecoxib can be increased when it is combined with Ceritinib. |
Clarithromycin | The serum concentration of Parecoxib can be increased when it is combined with Clarithromycin. |
Cobicistat | The serum concentration of Parecoxib can be increased when it is combined with Cobicistat. |
Darunavir | The serum concentration of Parecoxib can be increased when it is combined with Darunavir. |
Delavirdine | The serum concentration of Parecoxib can be increased when it is combined with Delavirdine. |
Dextromethorphan | The serum concentration of Dextromethorphan can be increased when it is combined with Parecoxib. |
Floxuridine | The serum concentration of Parecoxib can be increased when it is combined with Floxuridine. |
Fluconazole | The serum concentration of Parecoxib can be increased when it is combined with Fluconazole. |
Fluorouracil | The serum concentration of Parecoxib can be increased when it is combined with Fluorouracil. |
Gemfibrozil | The serum concentration of Parecoxib can be increased when it is combined with Gemfibrozil. |
Idelalisib | The serum concentration of Parecoxib can be increased when it is combined with Idelalisib. |
Indinavir | The serum concentration of Parecoxib can be increased when it is combined with Indinavir. |
Itraconazole | The serum concentration of Parecoxib can be increased when it is combined with Itraconazole. |
Ketoconazole | The serum concentration of Parecoxib can be increased when it is combined with Ketoconazole. |
Nefazodone | The serum concentration of Parecoxib can be increased when it is combined with Nefazodone. |
Nelfinavir | The serum concentration of Parecoxib can be increased when it is combined with Nelfinavir. |
Nicardipine | The serum concentration of Parecoxib can be increased when it is combined with Nicardipine. |
Posaconazole | The serum concentration of Parecoxib can be increased when it is combined with Posaconazole. |
Ritonavir | The serum concentration of Parecoxib can be increased when it is combined with Ritonavir. |
Saquinavir | The serum concentration of Parecoxib can be increased when it is combined with Saquinavir. |
Sulfadiazine | The serum concentration of Parecoxib can be increased when it is combined with Sulfadiazine. |
Telaprevir | The serum concentration of Parecoxib can be increased when it is combined with Telaprevir. |
Telithromycin | The serum concentration of Parecoxib can be increased when it is combined with Telithromycin. |
Tolbutamide | The serum concentration of Parecoxib can be increased when it is combined with Tolbutamide. |
Voriconazole | The serum concentration of Parecoxib can be increased when it is combined with Voriconazole. |
Food Interactions:
- Not Available
Taxonomy
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
- Aminosulfonyl compounds
- Azacyclic compounds
- Carbonyl compounds
- Carboxylic acid amides
- Heteroaromatic compounds
- Hydrocarbon derivatives
- Isoxazoles
- Organonitrogen compounds
- Oxacyclic compounds
- Oxazoles
- Sulfonamides
substituent:
- Aminosulfonyl compound
- Aromatic heteromonocyclic compound
- Azacycle
- Azole
- Benzenesulfonamide
- Carbonyl group
- Carboxamide group
- Carboxylic acid derivative
- Heteroaromatic compound
- Hydrocarbon derivative
- Isoxazole
- Organoheterocyclic compound
- Organonitrogen compound
- Organooxygen compound
- Organosulfur compound
- Oxacycle
- Oxazole
- Sulfonamide
- Sulfonic acid derivative
- Sulfonyl
References
General Reference: Not Available
External Links:
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ATC Codes:
- Array
AHFS Codes:
- Not Available
MSDS: Download