Detail

Parecoxib

Description

Name: Parecoxib
Type: small molecule
Groups: approved
Indication: Used for short term perioperative pain control.
Accession Number: DB08439 ( DB08439)
Description: Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. In 2005, the U.S. Food and Drug Administration (FDA) issued a letter of non-approval for parecoxib in the United States.
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients

Categories
  • No Category

Pharmacology

Indication: Used for short term perioperative pain control.
Pharmacodynamics: Not Available
Mechanism of action: Not Available
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: 98%
Metabolism: Not Available
Route of elimination: Not Available
Half life: 22 minutes (parecoxib); 8 hours (valdecoxib)
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
  • Not Available

Dosage forms
FormRouteStrength

Prices
Unit descriptionCostUnit

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction
AtazanavirThe serum concentration of Parecoxib can be increased when it is combined with Atazanavir.
BoceprevirThe serum concentration of Parecoxib can be increased when it is combined with Boceprevir.
CapecitabineThe serum concentration of Parecoxib can be increased when it is combined with Capecitabine.
CeritinibThe serum concentration of Parecoxib can be increased when it is combined with Ceritinib.
ClarithromycinThe serum concentration of Parecoxib can be increased when it is combined with Clarithromycin.
CobicistatThe serum concentration of Parecoxib can be increased when it is combined with Cobicistat.
DarunavirThe serum concentration of Parecoxib can be increased when it is combined with Darunavir.
DelavirdineThe serum concentration of Parecoxib can be increased when it is combined with Delavirdine.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Parecoxib.
FloxuridineThe serum concentration of Parecoxib can be increased when it is combined with Floxuridine.
FluconazoleThe serum concentration of Parecoxib can be increased when it is combined with Fluconazole.
FluorouracilThe serum concentration of Parecoxib can be increased when it is combined with Fluorouracil.
GemfibrozilThe serum concentration of Parecoxib can be increased when it is combined with Gemfibrozil.
IdelalisibThe serum concentration of Parecoxib can be increased when it is combined with Idelalisib.
IndinavirThe serum concentration of Parecoxib can be increased when it is combined with Indinavir.
ItraconazoleThe serum concentration of Parecoxib can be increased when it is combined with Itraconazole.
KetoconazoleThe serum concentration of Parecoxib can be increased when it is combined with Ketoconazole.
NefazodoneThe serum concentration of Parecoxib can be increased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Parecoxib can be increased when it is combined with Nelfinavir.
NicardipineThe serum concentration of Parecoxib can be increased when it is combined with Nicardipine.
PosaconazoleThe serum concentration of Parecoxib can be increased when it is combined with Posaconazole.
RitonavirThe serum concentration of Parecoxib can be increased when it is combined with Ritonavir.
SaquinavirThe serum concentration of Parecoxib can be increased when it is combined with Saquinavir.
SulfadiazineThe serum concentration of Parecoxib can be increased when it is combined with Sulfadiazine.
TelaprevirThe serum concentration of Parecoxib can be increased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Parecoxib can be increased when it is combined with Telithromycin.
TolbutamideThe serum concentration of Parecoxib can be increased when it is combined with Tolbutamide.
VoriconazoleThe serum concentration of Parecoxib can be increased when it is combined with Voriconazole.

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Aminosulfonyl compounds
  • Azacyclic compounds
  • Carbonyl compounds
  • Carboxylic acid amides
  • Heteroaromatic compounds
  • Hydrocarbon derivatives
  • Isoxazoles
  • Organonitrogen compounds
  • Oxacyclic compounds
  • Oxazoles
  • Sulfonamides

substituent:
  • Aminosulfonyl compound
  • Aromatic heteromonocyclic compound
  • Azacycle
  • Azole
  • Benzenesulfonamide
  • Carbonyl group
  • Carboxamide group
  • Carboxylic acid derivative
  • Heteroaromatic compound
  • Hydrocarbon derivative
  • Isoxazole
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Organooxygen compound
  • Organosulfur compound
  • Oxacycle
  • Oxazole
  • Sulfonamide
  • Sulfonic acid derivative
  • Sulfonyl

References

Synthesis Reference: Not Available
General Reference: Not Available
External Links:
ResourceLink

ATC Codes:
  • Array

AHFS Codes:
  • Not Available

MSDS: Download
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