Detail

Paramethasone

Description

Name: Paramethasone
Type: small molecule
Groups: approved
Indication: For the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone.
Accession Number: DB01384 ( DB01384)
Description: A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients

Categories
  • No Category

Pharmacology

Indication: For the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone.
Pharmacodynamics: Not Available
Mechanism of action: Glucocorticoids such as paramethasone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Paramethasone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: 80%
Metabolism: Not Available
Route of elimination: Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
Half life: Not Available
Clearance: Not Available
Toxicity: Side effects include inhibition of bone formation, suppression of calcium absorption delayed wound healing, immune suppression, and hyperglycemia.
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
  • Not Available

Dosage forms
FormRouteStrength

Prices
Unit descriptionCostUnit

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • 11-beta-hydroxysteroids
  • 17-hydroxysteroids
  • 20-oxosteroids
  • 3-oxo delta-1,4-steroids
  • Alkyl fluorides
  • Alpha-hydroxy ketones
  • Cyclic alcohols and derivatives
  • Cyclic ketones
  • Delta-1,4-steroids
  • Gluco/mineralocorticoids, progestogins and derivatives
  • Halogenated steroids
  • Hydrocarbon derivatives
  • Organofluorides
  • Primary alcohols
  • Secondary alcohols
  • Tertiary alcohols

substituent:
  • 11-beta-hydroxysteroid
  • 11-hydroxysteroid
  • 17-hydroxysteroid
  • 20-oxosteroid
  • 21-hydroxysteroid
  • 3-oxo-delta-1,4-steroid
  • 3-oxosteroid
  • 6-halo-steroid
  • Alcohol
  • Aliphatic homopolycyclic compound
  • Alkyl fluoride
  • Alkyl halide
  • Alpha-hydroxy ketone
  • Carbonyl group
  • Cyclic alcohol
  • Cyclic ketone
  • Delta-1,4-steroid
  • Halo-steroid
  • Hydrocarbon derivative
  • Ketone
  • Organofluoride
  • Organohalogen compound
  • Organooxygen compound
  • Oxosteroid
  • Pregnane-skeleton
  • Primary alcohol
  • Progestogin-skeleton
  • Secondary alcohol
  • Tertiary alcohol

References

Synthesis Reference: Not Available
General Reference: Not Available
External Links:
ResourceLink

ATC Codes:
  • Array

AHFS Codes:
  • Not Available

MSDS: Download
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