Detail

Pancuronium

Description

Name: Pancuronium
Type: small molecule
Groups: approved
Indication: Used as a muscle relaxant during anesthesia and surgical procedures.
Accession Number: DB01337 ( DB01337)
Description: A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
Structure:
Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Pancuronium Bromide - Liq IV 1mg/mlliquid1 mgintravenous31-12-1995Canada
Pancuronium Bromide - Liq IV 2mg/mlliquid2 mgintravenous31-12-1996Canada
Pancuronium Bromide 1mg/mlsolution1 mgintravenous24-10-1996Canada
Pancuronium Bromide 2mg/mlsolution2 mgintravenous31-12-1995Canada
Pavulon Inj 1mg/mlliquid1 mgintravenous31-12-197918-08-1997Canada
Pavulon Inj 2mg/mlliquid2 mgintravenous31-12-197318-08-1997Canada

Generic Prescription Products:
NameDosageStrengthRouteMarketing StartMarketing EndCountry
Pancuronium Bromideinjection, solution1 mg/mLintravenous19-01-1989US
Pancuronium Bromideinjection, solution1 mg/mLintravenous01-08-1990US
Pancuronium Bromideinjection, solution2 mg/mLintravenous01-08-1990US
Pancuronium Bromideinjection, solution2 mg/mLintravenous01-08-1990US

Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients
Pancuronium BromidePancuronium
Pancuronium BromidePancuronium
Pancuronium BromidePancuronium
Pancuronium BromidePancuronium
Pancuronium Bromide 2mg/mlPancuronium
Pancuronium Bromide - Liq IV 2mg/mlPancuronium
Pancuronium Bromide - Liq IV 1mg/mlPancuronium
Pancuronium Bromide 1mg/mlPancuronium
Pavulon Inj 2mg/mlPancuronium
Pavulon Inj 1mg/mlPancuronium

Categories
  • Neuromuscular Nondepolarizing Agents
  • Nicotinic Antagonists

Pharmacology

Indication: Used as a muscle relaxant during anesthesia and surgical procedures.
Pharmacodynamics: Not Available
Mechanism of action: Nondepolarizing neuromuscular blocking agents inhibit neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. This type of neuromuscular block is usually antagonized by anticholinesterase agents.
Absorption: Not Available
Volume of distribution:
  • 241 to 280 mL/kg

Protein binding: 77 to 91%
Metabolism: Not Available
Route of elimination: Not Available
Half life: 1.5 to 2.7 hours.
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
Dosage forms
FormRouteStrength
Injection, solutionintravenous1 mg/mL
Injection, solutionintravenous2 mg/mL
Liquidintravenous1 mg
Liquidintravenous2 mg
Solutionintravenous1 mg
Solutionintravenous2 mg

Prices
Unit descriptionCostUnit
Pancuronium 2 mg/ml vial$2.59ml
Pancuronium 1 mg/ml vial$0.13ml

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction
AmikacinAmikacin may increase the activities of Pancuronium.
AminophyllineThe risk or severity of adverse effects can be increased when Aminophylline is combined with Pancuronium.
AmlodipineAmlodipine may increase the neuromuscular blocking activities of Pancuronium.
AmrinoneAmrinone may increase the neuromuscular blocking activities of Pancuronium.
ArbekacinArbekacin may increase the activities of Pancuronium.
BepridilBepridil may increase the neuromuscular blocking activities of Pancuronium.
Botulinum Toxin Type ABotulinum Toxin Type A may increase the neuromuscular blocking activities of Pancuronium.
Botulinum Toxin Type BPancuronium may increase the neuromuscular blocking activities of Botulinum Toxin Type B.
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Pancuronium.
ClindamycinClindamycin may increase the neuromuscular blocking activities of Pancuronium.
ColistimethateColistimethate may increase the neuromuscular blocking activities of Pancuronium.
CyclosporineCyclosporine may increase the neuromuscular blocking activities of Pancuronium.
DigoxinPancuronium may increase the arrhythmogenic activities of Digoxin.
DyphyllineThe risk or severity of adverse effects can be increased when Dyphylline is combined with Pancuronium.
FelodipineFelodipine may increase the neuromuscular blocking activities of Pancuronium.
FludrocortisonePancuronium may increase the adverse neuromuscular activities of Fludrocortisone.
FlunarizineFlunarizine may increase the neuromuscular blocking activities of Pancuronium.
FramycetinFramycetin may increase the activities of Pancuronium.
GabapentinGabapentin may increase the neuromuscular blocking activities of Pancuronium.
GentamicinGentamicin may increase the activities of Pancuronium.
IsofluraneIsoflurane may increase the neuromuscular blocking activities of Pancuronium.
IsradipineIsradipine may increase the neuromuscular blocking activities of Pancuronium.
KanamycinKanamycin may increase the activities of Pancuronium.
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Pancuronium.
LamotrigineLamotrigine may increase the neuromuscular blocking activities of Pancuronium.
LercanidipineLercanidipine may increase the neuromuscular blocking activities of Pancuronium.
LincomycinLincomycin may increase the neuromuscular blocking activities of Pancuronium.
LithiumLithium may increase the neuromuscular blocking activities of Pancuronium.
Magnesium SulfateMagnesium Sulfate may increase the neuromuscular blocking activities of Pancuronium.
MinocyclineMinocycline may increase the neuromuscular blocking activities of Pancuronium.
NeomycinNeomycin may increase the activities of Pancuronium.
NetilmicinNetilmicin may increase the activities of Pancuronium.
NicardipineNicardipine may increase the neuromuscular blocking activities of Pancuronium.
NimodipineNimodipine may increase the neuromuscular blocking activities of Pancuronium.
NisoldipineNisoldipine may increase the neuromuscular blocking activities of Pancuronium.
NitrendipineNitrendipine may increase the neuromuscular blocking activities of Pancuronium.
OxytetracyclineOxytetracycline may increase the neuromuscular blocking activities of Pancuronium.
PerhexilinePerhexiline may increase the neuromuscular blocking activities of Pancuronium.
PhenytoinPhenytoin may decrease the neuromuscular blocking activities of Pancuronium.
Polymyxin B SulfatePolymyxin B Sulfate may increase the neuromuscular blocking activities of Pancuronium.
PrenylaminePrenylamine may increase the neuromuscular blocking activities of Pancuronium.
ProcainamideProcainamide may increase the neuromuscular blocking activities of Pancuronium.
QuinidineQuinidine may increase the neuromuscular blocking activities of Pancuronium.
QuinineQuinine may increase the neuromuscular blocking activities of Pancuronium.
RibostamycinRibostamycin may increase the activities of Pancuronium.
RisedronateRisedronate may increase the neuromuscular blocking activities of Pancuronium.
SpectinomycinSpectinomycin may increase the activities of Pancuronium.
SpironolactoneSpironolactone may increase the neuromuscular blocking activities of Pancuronium.
StreptomycinStreptomycin may increase the activities of Pancuronium.
TacrineTacrine may decrease the neuromuscular blocking activities of Pancuronium.
TheophyllineThe risk or severity of adverse effects can be increased when Theophylline is combined with Pancuronium.
TobramycinTobramycin may increase the activities of Pancuronium.
TorasemideTorasemide may decrease the neuromuscular blocking activities of Pancuronium.
VancomycinVancomycin may increase the neuromuscular blocking activities of Pancuronium.
VerapamilVerapamil may increase the neuromuscular blocking activities of Pancuronium.

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Acetate salts
  • Amines
  • Androstane steroids
  • Azacyclic compounds
  • Carbonyl compounds
  • Carboxylic acid esters
  • Cyclohexylamines
  • Hydrocarbon derivatives
  • Organic cations
  • Piperidines
  • Quaternary ammonium salts

substituent:
  • Acetate salt
  • Aliphatic heteropolycyclic compound
  • Amine
  • Androstane-skeleton
  • Azacycle
  • Carbonyl group
  • Carboxylic acid derivative
  • Carboxylic acid ester
  • Cyclohexylamine
  • Hydrocarbon derivative
  • Organic cation
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Organooxygen compound
  • Piperidine
  • Quaternary ammonium salt
  • Steroid ester

References

Synthesis Reference: Not Available
General Reference: Not Available
External Links:
ResourceLink

ATC Codes:
  • Array

AHFS Codes:
  • 12:20.00

MSDS: Download
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