Detail

Pagoclone

Description

Name: Pagoclone
Type: small molecule
Groups: investigational
Indication: For the potential treatment of panic and anxiety disorders.
Accession Number: DB04903 ( DB04903)
Description: Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other more well known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures.
Structure:
Prescription Products: Not Available
Generic Prescription Products: Not Available
Over the Counter Products: Not Available
International Brands
  • No Brands

Brand Names
  • No Brands

Brand Mixtures
Brand NameIngredients

Categories
  • Hypnotics and Sedatives

Pharmacology

Indication: For the potential treatment of panic and anxiety disorders.
Pharmacodynamics: Not Available
Mechanism of action: Pagoclone is a subtype-selective drug which binds primarily to the alpha2/alpha3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the alpha1 subtype which produces the sedative and memory loss effects.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms
  • Not Available

SNP Mediated Adverse Drug Reactions
  • Not Available

Pharmacoeconomics

Manufacturers:
  • Not Available

Packagers:
  • Not Available

Dosage forms
FormRouteStrength

Prices
Unit descriptionCostUnit

Patents
CountryPatent NumberApprovedExpires (estimated)

Interactions

Drug Interactions
DrugInteraction

Food Interactions:
  • Not Available

Taxonomy

Kingdom: Organic compounds
Super Class: Not Available
Class: Not Available
Sub Class: Not Available
Direct Parent: Not Available
Alternative Parents:
  • Aminopyridines and derivatives
  • Aryl chlorides
  • Azacyclic compounds
  • Benzenoids
  • Beta-amino ketones
  • Carboxylic acid amides
  • Heteroaromatic compounds
  • Hydrocarbon derivatives
  • Imidolactams
  • Isoindoles
  • Isoindolones
  • Lactams
  • Organochlorides
  • Tertiary amines

substituent:
  • Amine
  • Aminopyridine
  • Aromatic heteropolycyclic compound
  • Aryl chloride
  • Aryl halide
  • Azacycle
  • Benzenoid
  • Beta-aminoketone
  • Carbonyl group
  • Carboxamide group
  • Carboxylic acid derivative
  • Heteroaromatic compound
  • Hydrocarbon derivative
  • Imidolactam
  • Isoindole
  • Isoindole or derivatives
  • Isoindoline
  • Isoindolone
  • Ketone
  • Lactam
  • Naphthyridine
  • Organochloride
  • Organohalogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Pyridine
  • Tertiary amine

References

Synthesis Reference: Not Available
General Reference: # de Wit H, Vicini L, Haig GM, Hunt T, Feltner D: Evaluation of the abuse potential of pagoclone, a partial GABAA agonist. J Clin Psychopharmacol. 2006 Jun;26(3):268-73. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16702891 # Atack JR, Pike A, Marshall G, Stanley J, Lincoln R, Cook SM, Lewis RT, Blackaby WP, Goodacre SC, McKernan RM, Dawson GR, Wafford KA, Reynolds DS: The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone. Neuropharmacology. 2006 May;50(6):677-89. Epub 2006 Jan 20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16430927 # Bateson A: Pagoclone Indevus. Curr Opin Investig Drugs. 2003 Jan;4(1):91-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12625036 # Sandford JJ, Forshall S, Bell C, Argyropoulos S, Rich A, D'Orlando KJ, Gammans RE, Nutt DJ: Crossover trial of pagoclone and placebo in patients with DSM-IV panic disorder. J Psychopharmacol. 2001 Sep;15(3):205-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11565630
External Links:
ResourceLink

ATC Codes:
  • Not Available

AHFS Codes:
  • Not Available

MSDS: Download
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